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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Tinospora cordifolia

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


BIOLOGICAL MODELS

Test System Normal
tissue/tumor
Type of assay
/endpoint
Mice in vivo
Swiss albino mice macrophage and spleen(splenocytes) detemination of spleen size, weight, macrophage function assay, DNA fragmentation and apoptosis assay, splenocyte count and proliferation assay[1]
Swiss albino female mice ovary Follicle cell counts[2]
Swiss albino male mice blood serum determination of level of proteins, cholesterol and LPO[3]
Swiss albino male mice spleen and bone marrow micronucleus assay, CFU assay, survival, total leucocyte count[4]
female Swiss albino mice bearing Ehrlich ascites carcinoma determination of Mean survival time and average survival time, biochemical analysis[5]
male Swiss albino mice testicular tissue Determination of body weight, testes- body weight ratio, Testicular Histopathology[6]
male Swiss albino mice liver lipid peroxidation assay, biochemical analysis[7]
Swiss albino mice liver, spleen lipid peroxidation assay, Glutathione assay, Endogenous spleen colony forming unit (CFU) Assay:[8]
mice in vivo small intestine lipid peroxidation assay, thiols and SOD Assay[9]
Swiss albino mice intestine mitotic index and crypt of villi count, histopathology, determination of hematological parameters[10]
Swiss albino mice survival assay[11]
Wistar albino mice Micronucleus assay, Endogenous spleen colony forming unit assay and hematological parameters determination[14]
Swiss albino mice testis histology and biochemical parameter analysis[15]
In vitro study
HeLa cells clonogenic assay[12]
HeLa S3 cells Pratt and Willis assay and clonogenic assay[13]
REFERENCES:
1. Singh L et al, Effect of Tinospora cordifolia on Gamma ray-induced perturbations in macrophages and splenocytes. J. Radiat. Res.2007; 48(4): 305–315.
http://dx.doi.org/10.1269/jrr.07001
2. Sharma R, In vivo delivery of Tinospora cordifolia root extract preventing radiation-induced dystrophies in mice ovaries. Evidence-Based Complementary and Alternative Medicine Volume 2015, Article ID 346427, 7 pages.
http://dx.doi.org/10.1155/2015/346427
3. Sharma P, Goyal PK, Modulation of biochemical and antioxidant enzymes in blood by Tinospora cordifolia against gamma radiation mediated damage in mice. Asian J Pharm Clin Res. 2015;8(3):106-112.
http://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/4662/2434
4. Goel HC et al, Radioprotective poential of an herbal extract of Tinospora cordifolia. J. Radiat. Res. 2004;45(1):61-68.
http://dx.doi.org/10.1269/jrr.45.61
5. Rao SK, Rao PS, Rao BN, Preliminary investigation of the radiosensitizing activity of Guduchi (Tinospora cordifolia) in ttumor-bearing mice. Phytother. Res. 2008;22:1482–1489.
http://dx.doi.org/10.1002/ptr.2508
6. Sharma P et al, Radiation-induced testicular injury and its amelioration by Tinospora cordifolia (an Indian medicinal plant) extract. Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 643847, 9 pages.
http://dx.doi.org/10.1155/2011/643847
7. Sharma R, Sharma P, Goyal PK, Appraising radioprotective potential of Tinospora cordifolia (Amrita) extract in Swiss albino mice exposed to different doses of gamma radiation. Pharmacologyonline. 2009; 2: 249-260.
http://pharmacologyonline.silae.it/files/archives/2009/vol2/023.Sharma.pdf
8. Sharma P, Goyal PK, Protective action of Tinospora cordifolia extractagainst radiation induced biochemical alterations in liver. Int J Pharm Pharm Sci. 2014;6(6):305-311.
http://www.ijppsjournal.com/Vol6Issue6/9603.pdf
9. Tyagi S et al, Augmentation of antioxidant defense system by Tinospora cordifolia: implications in radiation protection. Journal of Complementary and Integrative Medicine. 2009;6(1):1553-3840.
http://dx.doi.org/10.2202/1553-3840.1322
10. Verma N, Khosa RL, Pathak AK, Evaluation of tissue protective activity of Tinospora cordifolia stems in irradiated Swiss albino mice with 60Co radiation. Journal of Natural Remedies. 2010; 10/1: 32 - 35.
http://www.informaticsjournals.com/index.php/jnr/article/view/423/423
11. Pahadiya S, Sharma J, Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytother. Res. 2003; 17:552–554.
http://dx.doi.org/10.1002/ptr.1156
12. Jagetia GC, Nayak V, Vidhyasagar MS, Enhancement of radiation effect by Guduchi (Tinospora cordifolia) in HeLa cells. Pharmaceutical Biology. 2002;40(3):179-188.
http://cat.inist.fr/?aModele=afficheN&cpsidt=13754577
13. Rao SK, Rao PS, Alteration in the radiosensitivity of HeLa cells by Dichloromethane extract of Guduchi (Tinospora cordifolia). Integrative Cancer Therapies 2010; 9(4): 378–384.
http://dx.doi.org/10.1177/1534735410387598
14. Patel A et al, Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A. Indian J Pharmacol. 2013; 45(3): 237–243.
http://dx.doi.org/10.4103/0253-7613.111919
15. Sharma P et al, Radiation induced oxidative stress and its toxicity in testes of mice and their prevention by Tinospora cordifolia extract. Journal of Reproductive Health and Medicine. 2015; 1(2):64–75.
http://dx.doi.org/10.1016/j.jrhm.2015.01.005