Welcome to University of Mumbai, Department of Biophysics

Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

Alphabetical Search   >  T   >  Tinospora cordifolia                                                                                                                                                                 Top

Tinospora cordifolia

Go To:

General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


Test System Normal
Type of assay
Mice in vivo
Swiss albino mice macrophage and spleen(splenocytes) detemination of spleen size, weight, macrophage function assay, DNA fragmentation and apoptosis assay, splenocyte count and proliferation assay[1]
Swiss albino female mice ovary Follicle cell counts[2]
Swiss albino male mice blood serum determination of level of proteins, cholesterol and LPO[3]
Swiss albino male mice spleen and bone marrow micronucleus assay, CFU assay, survival, total leucocyte count[4]
female Swiss albino mice bearing Ehrlich ascites carcinoma determination of Mean survival time and average survival time, biochemical analysis[5]
male Swiss albino mice testicular tissue Determination of body weight, testes- body weight ratio, Testicular Histopathology[6]
male Swiss albino mice liver lipid peroxidation assay, biochemical analysis[7]
Swiss albino mice liver, spleen lipid peroxidation assay, Glutathione assay, Endogenous spleen colony forming unit (CFU) Assay:[8]
mice in vivo small intestine lipid peroxidation assay, thiols and SOD Assay[9]
Swiss albino mice intestine mitotic index and crypt of villi count, histopathology, determination of hematological parameters[10]
Swiss albino mice survival assay[11]
Wistar albino mice Micronucleus assay, Endogenous spleen colony forming unit assay and hematological parameters determination[14]
Swiss albino mice testis histology and biochemical parameter analysis[15]
In vitro study
HeLa cells clonogenic assay[12]
HeLa S3 cells Pratt and Willis assay and clonogenic assay[13]
1. Singh L et al, Effect of Tinospora cordifolia on Gamma ray-induced perturbations in macrophages and splenocytes. J. Radiat. Res.2007; 48(4): 305–315.
2. Sharma R, In vivo delivery of Tinospora cordifolia root extract preventing radiation-induced dystrophies in mice ovaries. Evidence-Based Complementary and Alternative Medicine Volume 2015, Article ID 346427, 7 pages.
3. Sharma P, Goyal PK, Modulation of biochemical and antioxidant enzymes in blood by Tinospora cordifolia against gamma radiation mediated damage in mice. Asian J Pharm Clin Res. 2015;8(3):106-112.
4. Goel HC et al, Radioprotective poential of an herbal extract of Tinospora cordifolia. J. Radiat. Res. 2004;45(1):61-68.
5. Rao SK, Rao PS, Rao BN, Preliminary investigation of the radiosensitizing activity of Guduchi (Tinospora cordifolia) in ttumor-bearing mice. Phytother. Res. 2008;22:1482–1489.
6. Sharma P et al, Radiation-induced testicular injury and its amelioration by Tinospora cordifolia (an Indian medicinal plant) extract. Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 643847, 9 pages.
7. Sharma R, Sharma P, Goyal PK, Appraising radioprotective potential of Tinospora cordifolia (Amrita) extract in Swiss albino mice exposed to different doses of gamma radiation. Pharmacologyonline. 2009; 2: 249-260.
8. Sharma P, Goyal PK, Protective action of Tinospora cordifolia extractagainst radiation induced biochemical alterations in liver. Int J Pharm Pharm Sci. 2014;6(6):305-311.
9. Tyagi S et al, Augmentation of antioxidant defense system by Tinospora cordifolia: implications in radiation protection. Journal of Complementary and Integrative Medicine. 2009;6(1):1553-3840.
10. Verma N, Khosa RL, Pathak AK, Evaluation of tissue protective activity of Tinospora cordifolia stems in irradiated Swiss albino mice with 60Co radiation. Journal of Natural Remedies. 2010; 10/1: 32 - 35.
11. Pahadiya S, Sharma J, Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytother. Res. 2003; 17:552–554.
12. Jagetia GC, Nayak V, Vidhyasagar MS, Enhancement of radiation effect by Guduchi (Tinospora cordifolia) in HeLa cells. Pharmaceutical Biology. 2002;40(3):179-188.
13. Rao SK, Rao PS, Alteration in the radiosensitivity of HeLa cells by Dichloromethane extract of Guduchi (Tinospora cordifolia). Integrative Cancer Therapies 2010; 9(4): 378–384.
14. Patel A et al, Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A. Indian J Pharmacol. 2013; 45(3): 237–243.
15. Sharma P et al, Radiation induced oxidative stress and its toxicity in testes of mice and their prevention by Tinospora cordifolia extract. Journal of Reproductive Health and Medicine. 2015; 1(2):64–75.