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"Radiosensitisers and Radioprotectors"

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Syzygium cumini

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


BIOLOGICAL MODELS

Test System Normal
tissue/tumor
Type of assay
/endpoint
Mice in vivo
Male Swiss albino mice Survival (LD50/30) assay[1]
Male Swiss albino mice Splenocytes(spleen), brain homogenate Micronucleus assay, TBARS assay[2]
Male Swiss albino mice analysis of 30-day survival[3]
Male Swiss albino mice small intestine histological study, determination of crypt number and villus height and length[4]
Swiss albino mice liver, spleen, intestine, fibrosarcoma Analysis of biochemical parameters, LPO assay[5]
In vitro study
human in vitro peripheral blood lymphocytes micronucleus assay[6]
mice in vitro peripheral blood leucocytes alkaline comet assay[5]
REFERENCES:
1. Jagetia GC, Baliga MS, Venkatesh P, Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of γ -radiation. J. Radiat. Res. 2005; 46(1): 59–65.
http://dx.doi.org/10.1269/jrr.46.59
2. Jagetia GC, Shetty PC, Vidyasagar MS, Inhibition of radiation-induced DNA damage by Jamun, Syzygium cumini, in the cultured splenocytes of mice exposed to different doses of γ-radiation. Integrative Cancer Therapies. 2012; 11(2): 141– 153.
http://dx.doi.org/10.1177/1534735411413261
3. Jagetia GC, Baliga MS, Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation. Nahrung/Food. 2003;47(3):181 – 185.
http://dx.doi.org/10.1002/food.200390042
4. Jagetia GC, Shetty PC, Vidyasagar MS, Treatment of mice with leaf extract of jamun(Syzygium cumini Linn. Skeels)protects against the radiation-induced damage in the intestinal mucosa of mice exposed to different doses of γ-radiation. Pharmacologyonline. 2008; 1: 169-195.
http://pharmacologyonline.silae.it/files/archives/2008/vol1/18_Ganesh.pdf
5. Sharma A, Soyal D, Goyal PK, Radioprotection by seed extract of Syzygium cumini in normal tissues of fibrosarcoma bearing mice. Indian Society for Radiation Biology, Delhi (India); K.S. Hegde Medical Academy, Mangalore (India); 90 p; Oct 2013; p. 61; ICRB-2013: international conference on radiation biology and clinical applications; Mangalore (India); 25-27 Oct 2013.
https://inis.iaea.org/search/search.aspx?orig_q=RN:45108336
6. Jagetia GC, Baliga MS, Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicology Letters. 2002; 132(1) : 19–25.
http://dx.doi.org/10.1016/S0378-4274(02)00032-2