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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Rubia cordifolia

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


BIOLOGICAL MODELS

Test System Normal
tissue/tumor
Type of assay
/endpoint
mice in vivo
Male Swiss Albino mice spleen and bone marrow alkaline comet assay[1]
Percentage survival determination[1]
liver, bone marrow erythrocytes, hematopoietic stem cells TBARS assay, micronucleus assay, endogenous colony forming units assay[2]
In vitro study
plasmid pBR322 Calculation of Dose Modification Factor[1]
Swiss albino mouse in vitro Splenocyte and thymocyte trypan blue dye exclusion method[1]
human ex vivo peripheral leucocytes comet assay[1]
plasmid pBR322 single strand breaks determination[3]
Rat in vitro liver mitochondria biochemical analysis[3]
REFERENCES:
1. Chapter 5 : Radioprotective, nephoprotective and anti-inflammatory activities of the plant Rubia cordifolia Linn. ; In : Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance, a thesis by Joy J, Guide : Nair CKK, submitted to Mahatma Gandhi University, Amala Cancer Research Center, India, 2014.
http://shodhganga.inflibnet.ac.in/handle/10603/25801
2. Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology 2007; 45(7):620-625.
http://nopr.niscair.res.in/bitstream/123456789/5335/1/IJEB%2045(7)%20620-625.pdf
3. Kamat JP, Mishra, KP, Radioprotection by Rubia cordifolia: studies on mitochondrial membranes. Sixteenth annual conference of Indian Nuclear Society: science behind nuclear technology. Mumbai (India)Íž 15-18 Nov 2005.
https://inis.iaea.org/search/search.aspx?orig_q=RN:37061834