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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Nigella sativa

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


Test System Normal
Type of assay
Mice in vivo
Swiss albino mice free radical scavenging activity assay, LD50/30 assay[1]
Swiss female mice spleen, liver, bone marrow micronuclei assay, antioxidative enzyme assays, comet assay, TBARS assay[2]
female Swiss albino mice liver, spleen, intestines and brain, blood leukocytes TBARS assay, alkaline comet assay, antioxidative enzyme assay[3]
female Swiss albino mice bearing fibrosarcoma
rats in vivo
Sprague-Dawley rats tongue measurement of TAS and TOS, OSI, LOOH and -SH levels[4]
Sprague-Dawley rats lens biochemical analysis[5]
albino rats liver, kidney ultrastructure study[6]
male albino Wistar rats brain Nitric oxide synthase activity assay[7]
male Wistar albino rats spleen and thymus lymphoid follicles protein estimation, TBARS assay, histological study, leukocyte count, LD50/30 assay[8]
male Wistar albino rats peripheral blood lymphocytes ANAE staining, TBARS assay, determination of level nonenzymatic antioxidant markers[9]
Sprague-Dawley rats liver Measurement of TAS-TOS, -SH, and LOOH Levels and Calculation of OSI, enzyme assay[10]
Sprague-Dawley rats lens Chylack' cataract classification, enzyme assay[11]
male rats T lymphocytes,thymus TBARS assay, lipid profile analysis, flow cytometric analysis, apoptosis assay, histological study[12]
male CF rats intestine TBARS assay, antioxidative enzyme assay, intestinal morphological study[13]
In vitro study
mice ex vivo splenic lymphocytes TBARS assay, comet assay[2]
Plasmid pBR322 DNA Gel electrophoresis(plasmid relaxation study)[2]
1. Jagetia GC, Ravikiran PB, Radioprotective potential of Nigella Sativa extract in Swiss Albino Mice exposed to whole Body γ-radiation. Altern Integr Med 2014; 3(4):1-9.
2. Rastogi L et l, Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L. Int. J. Radiat. Biol. 2010;86(9):719–731.
3. Velho-Pereira R et al, Radioprotection by macerated extract of Nigella sativa in normal tissues of fibrosarcoma bearing mice. Indian J Pharm Sci. 2012; 74(5): 403–414.
http://dx.doi.org/10.4103/0250474X. 108415
4. Üstün K et al, Radio-protective effects of Nigella sativa oil on oxidative stress in tongue tissue of rat. Oral Diseases 2014; 20(1):109–113.
5. Taysi S et al, The radioprotective effect of Nigella sativa on nitrosative stress in lens tissue in radiation-induced cataract in rat. Cutan Ocul Toxicol. 2014; Early Online: 1–6.
6. Abdel-Azeem MG, Evaluation of the radioprotective and curative role of a natural antioxidant against cellular ultrastructural hazards induced in rats by gamma radiation exposure. Isotope and Radiation Research. 2005; 37(6):1509-1523.
7. Ahlatci A et al, Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue. Phytomedicine 2014;21:740–744.
8. Assayed ME, Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacology and Immunotoxicology 2010; 32(2): 284–296
9. Cemek M et al, In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats. Photochemistry and Photobiology 2006; 82: 1691-1696.
10. Cikman O et al, Radioprotective effects of Nigella sativa oil against oxidative stress in liver tissue of rats exposed to total head irradiation. Journal of Investigative Surgery 2014; 27: 262–266.
11. Demir E et al, The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract. Wien Klin Wochenschr. 2015 Apr 10.
12. Guida MS et al, Thymoquinone rescues T Lymphocytes from gamma irradiation-induced apoptosis and exhaustion by modulating pro-inflammatory cytokine levels and PD-1, Bax, and Bcl-2 signaling. Cell Physiol Biochem 2016;38:786-800.
13. Pandey N et al, Effect of methanolic fraction of the seeds of Nigella sativa Linn on radiation induced GI damage in rats. Nutr Food Technol. 2015; 1(1):1-5.