| Toxicity values: |
LD50 for ethanolic pulp extract was foundto be above 2000mg/kg in Albino rats in vivo[1]
The ethanolic extract of Eugenia jambolana seed extract(100 and 200 mg/kg body weight for 20 days) is found to be toxic to albino rat liver as
evident by increase in liver enzyme levels(ALT, gamma GT) and disturbed liver histology[2]
safety of acute(300, 2000, and 5000 mg/kg body
weight) and repeated(300, 1000, and 2000 mg/kg body
weight, and animals were observed till the 28th day of treatment) oral administration of the aqueous extract of
stem bark in Swiss albino mice and Wistar rats in vivo has been demonstrated[3]
LD50 oral for ethanolic seed extract in Swiss albino mice was found to be >5000mg/kg BW. The lowest observable adverse effect level for ethanolic seed extract was found to be 3000 mg/kg BW[4]
|
| Adverse reactions: |
|
| Effect on various metabolisms/pathways: |
|
| Mutagenicity or Carcinogen-icity Data: |
hydroalcoholic leaf extract showed antimutagenic potential in rats in vivo[5]
Syzygium cummini extract
exhibited anti-tumor and anti-oxidative potential against benzo-a-pyrene (BaP)-induced gastric carcinogenesis in mice in vivo[6]
S. cumini seed extract prevented peroxidative damage due to DMBA contributing to
skin papillomagenesis in Swiss albino mice in vivo[7]
The in vivo experiments with aqueous seed extract
showed significant protective effects against chromosomal damage induced by the genotoxic
carcinogens Urethane and DMBA.[8]
|
| Fertility: |
The administration of the
Oleanolic acid from flowers of E. jambolana for 60 days decreased the
fertilizing capacity of the male albino rats without
any significant changes in body weight or
reproductive organ weights[9]
|
| Pregnancy: |
|
| Breast Feeding: |
|
| REFERENCES |
| 1. |
Das S, Sarma G, Study of the hepatoprotective activity of the ethanolic extract of the pulp of Eugenia
jambolana (Jamun) in Albino rats. Journal of Clinical and Diagnostic Research. 2009;3(2):1466-1474.
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.576.342 |
| 2. |
Rasheed S et al, Histological effects of Eugenia jambolana seed extract on liver of adult
albino rats. J Ayub Med Coll Abbottabad. 2009;21(1):148-51.
http://www.ncbi.nlm.nih.gov/pubmed/20364766 |
| 3. |
Yele SU, Veeranjaneyulu A, Toxicological assessments of aqueous extract of
Eugenia jambolana stem bark. Pharmaceutical Biology. 2010; 48(8): 849–854.
http://dx.doi.org/10.3109/13880200903300204 |
| 4. |
Sankhari JM et al, Safety evaluation of Eugenia jambolana seed extract. Asian Pacific Journal of Tropical Medicine.
2010;3(12):982-987.
http://dx.doi.org/10.1016/S1995-7645(11)60014-X |
| 5. |
Donya SM, Ibrahim NH, Antimutagenic Potential of Cynara scolymus, Cupressus sempervirens and Eugenia jambolana Against paracetamol-induced liver cytotoxicity. Journal of American Science. 2012; 8(1):61-67.
http://www.jofamericanscience.org/journals/am-sci/am0801/009_7679am0801_61_67.pdf |
| 6. |
Goyal PK et al, Evaluation of anti-cancer and anti-oxidative potential of Syzygium Cumini
against benzo[a]pyrene (BaP) induced gastric carcinogenesis in mice. Asian Pac J Cancer Prev. 2010;11(3):753-8.
http://www.ncbi.nlm.nih.gov/pubmed/21039048 |
| 7. |
Parmar J et al, Chemopreventive action of Syzygium cumini on DMBA-induced skin
papillomagenesis in mice. Asian Pac J Cancer Prev. 2010;11(1):261-5.
http://www.ncbi.nlm.nih.gov/pubmed/20593968 |
| 8. |
Arun R et al, Role of Syzygium cumini seed extract in the chemoprevention of in vivo
genomic damage and oxidative stress. J Ethnopharmacol. 2011;134(2):329-33.
http://dx.doi.org/10.1016/j.jep.2010.12.014 |
| 9. |
Rajasekharan M et al, Antifertility effect in male rats
of oleanolic acid, a triterpene
from Eugenia jambolana
flowers. Journal of
Ethnopharmacology.
1988;24(1):115-121.
http://dx.doi.org/10.1016/0378-8741(88)90142-0 |
