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Syzygium cumini

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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TOXICITY

Toxicity
values:
LD50 for ethanolic pulp extract was foundto be above 2000mg/kg in Albino rats in vivo[1]
The ethanolic extract of Eugenia jambolana seed extract(100 and 200 mg/kg body weight for 20 days) is found to be toxic to albino rat liver as evident by increase in liver enzyme levels(ALT, gamma GT) and disturbed liver histology[2]
safety of acute(300, 2000, and 5000 mg/kg body weight) and repeated(300, 1000, and 2000 mg/kg body weight, and animals were observed till the 28th day of treatment) oral administration of the aqueous extract of stem bark in Swiss albino mice and Wistar rats in vivo has been demonstrated[3]
LD50 oral for ethanolic seed extract in Swiss albino mice was found to be >5000mg/kg BW. The lowest observable adverse effect level for ethanolic seed extract was found to be 3000 mg/kg BW[4]
Adverse
reactions:
Effect on
various
metabolisms/
pathways:
Mutagenicity
or Carcinogen-
icity Data:
hydroalcoholic leaf extract showed antimutagenic potential in rats in vivo[5]
Syzygium cummini extract exhibited anti-tumor and anti-oxidative potential against benzo-a-pyrene (BaP)-induced gastric carcinogenesis in mice in vivo[6]
S. cumini seed extract prevented peroxidative damage due to DMBA contributing to skin papillomagenesis in Swiss albino mice in vivo[7]
The in vivo experiments with aqueous seed extract showed significant protective effects against chromosomal damage induced by the genotoxic carcinogens Urethane and DMBA.[8]
Fertility: The administration of the Oleanolic acid from flowers of E. jambolana for 60 days decreased the fertilizing capacity of the male albino rats without any significant changes in body weight or reproductive organ weights[9]
Pregnancy:
Breast Feeding:
REFERENCES
1. Das S, Sarma G, Study of the hepatoprotective activity of the ethanolic extract of the pulp of Eugenia jambolana (Jamun) in Albino rats. Journal of Clinical and Diagnostic Research. 2009;3(2):1466-1474.
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.576.342
2. Rasheed S et al, Histological effects of Eugenia jambolana seed extract on liver of adult albino rats. J Ayub Med Coll Abbottabad. 2009;21(1):148-51.
http://www.ncbi.nlm.nih.gov/pubmed/20364766
3. Yele SU, Veeranjaneyulu A, Toxicological assessments of aqueous extract of Eugenia jambolana stem bark. Pharmaceutical Biology. 2010; 48(8): 849–854.
http://dx.doi.org/10.3109/13880200903300204
4. Sankhari JM et al, Safety evaluation of Eugenia jambolana seed extract. Asian Pacific Journal of Tropical Medicine. 2010;3(12):982-987.
http://dx.doi.org/10.1016/S1995-7645(11)60014-X
5. Donya SM, Ibrahim NH, Antimutagenic Potential of Cynara scolymus, Cupressus sempervirens and Eugenia jambolana Against paracetamol-induced liver cytotoxicity. Journal of American Science. 2012; 8(1):61-67.
http://www.jofamericanscience.org/journals/am-sci/am0801/009_7679am0801_61_67.pdf
6. Goyal PK et al, Evaluation of anti-cancer and anti-oxidative potential of Syzygium Cumini against benzo[a]pyrene (BaP) induced gastric carcinogenesis in mice. Asian Pac J Cancer Prev. 2010;11(3):753-8.
http://www.ncbi.nlm.nih.gov/pubmed/21039048
7. Parmar J et al, Chemopreventive action of Syzygium cumini on DMBA-induced skin papillomagenesis in mice. Asian Pac J Cancer Prev. 2010;11(1):261-5.
http://www.ncbi.nlm.nih.gov/pubmed/20593968
8. Arun R et al, Role of Syzygium cumini seed extract in the chemoprevention of in vivo genomic damage and oxidative stress. J Ethnopharmacol. 2011;134(2):329-33.
http://dx.doi.org/10.1016/j.jep.2010.12.014
9. Rajasekharan M et al, Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers. Journal of Ethnopharmacology. 1988;24(1):115-121.
http://dx.doi.org/10.1016/0378-8741(88)90142-0