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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Rubia cordifolia

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


TOXICITY

Toxicity
values:
The LD50 value for the alcoholic root extract was found to be 1200 mg/kg body weight at 72 hr after irradiation in Swiss albino mice of strain A[1]
Adverse
reactions:
Effect on
various
metabolisms/
pathways:
Mutagenicity
or Carcinogen-
icity Data:
alizarin from Rubia cordifolia possessed significant modulatory role against the genotoxicity of mutagens[2]
Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma has been demonstrated[3]
Fertility: Ethanolic root extract administered orally at 250 mg/kg dose, in days 1-7 of pregnancy in albino rats, showed 33.33% of antifertility activity[4]
Pregnancy:
Breast Feeding:
REFERENCES
1. Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology 2007; 45(7):620-625.
http://nopr.niscair.res.in/bitstream/123456789/5335/1/IJEB%2045(7)%20620-625.pdf
2. Kaur P et al, Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food Chem Toxicol. 2010 ;48(1):320-5.
http://dx.doi.org/10.1016/j.fct.2009.10.019
3. Shilpa PN, Venkatabalasubramanian S, Devaraj SN, Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma. Pharm Biol. 2012 ;50(3):376-83.
http://dx.doi.org/10.3109/13880209.2011.608073
4. Sharma BB et al, Antifertility screening of plants. Part I. effect of ten indigenous plants on early pregnancy in Albino rats. Int. J. Crude Drug Res. 1983; 21(4) :183-187.
http://dx.doi.org/10.3109/13880208309070640