| Toxicity values: |
The LD50 value for the alcoholic root extract was found to be 1200 mg/kg body weight
at 72 hr after irradiation in Swiss albino mice of strain A[1]
|
| Adverse reactions: |
|
| Effect on various metabolisms/pathways: |
|
| Mutagenicity or Carcinogen-icity Data: |
alizarin from Rubia cordifolia possessed significant modulatory role against the genotoxicity of mutagens[2]
Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma has been demonstrated[3]
|
| Fertility: |
Ethanolic root extract administered orally at 250 mg/kg dose, in days 1-7 of pregnancy in albino rats, showed 33.33% of antifertility activity[4]
|
| Pregnancy: |
|
| Breast Feeding: |
|
| REFERENCES |
| 1. |
Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology
2007; 45(7):620-625.
http://nopr.niscair.res.in/bitstream/123456789/5335/1/IJEB%2045(7)%20620-625.pdf |
| 2. |
Kaur P et al, Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of
mutagens. Food Chem Toxicol. 2010 ;48(1):320-5.
http://dx.doi.org/10.1016/j.fct.2009.10.019 |
| 3. |
Shilpa PN, Venkatabalasubramanian S, Devaraj SN, Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced
hepatocellular carcinoma. Pharm Biol. 2012 ;50(3):376-83.
http://dx.doi.org/10.3109/13880209.2011.608073 |
| 4. |
Sharma BB et al, Antifertility screening of plants. Part I. effect of ten
indigenous plants on early pregnancy in Albino rats. Int. J. Crude Drug Res. 1983; 21(4) :183-187.
http://dx.doi.org/10.3109/13880208309070640 |
