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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Target - Nucleic acids
Drug/chemical/plant extract/supplement Mechanism
AET(2-aminoethylisothiouronium bromide hydrobromide) Production of tissue anoxia and/or scavenging of free radicals
Protection against radiation-induced micronuclei formation and chromosomal aberrations.
Actinomycin D It intercalates in DNA forming a complex.
Inhibits chemical repair of radiation-induced DNA damage
Interefers with elongation step of RNA synthesis
Bixa orellana extract reduces radiation-induced cheromosomal aberration
scavenging of free radicals
Etanidazole radiosensitization of hypoxic cells and also inhibition of potentially lethal damage (PLD) repair
Glyzyrrhizic acid protection against radiation-induced DNA damage
free radical scavenging activity
Gimeracil enhance the efficacy of radiotherapy through partial suppression of Homologus recombination-mediated DNA repair pathways
Mitomycin C lowers the frequency of radiation-induced micronuclei formation
Motexafin Gadolinium MGd causes both DNA damage and disrupts DNA repair via inhibition of ribonucleotide repair
MLN 4924 reduces radiation-induced DNA damage
Target - Lipids
Drug/chemical/plant extract/supplement Mechanism
Mentha spicata reduces lipid peroxidation
free radical scavenging activity
Probucol reduces lipid peroxidation
free radical scavenging activity
Rhodiola imbricata reduces lipid peroxidation
free radical scavenging activity
Target - Proteins
Drug/chemical/plant extract/supplement Mechanism
Artemisinin Alleviates of the G2-phase block
Down-regulation of Wee1 and up-regulation of cyclin B1
Decreases repair ability after sublethal injury in vitro
Ageratum conyzoides extract Free radical scavenging
Increases level of GSH
Induced immunomodulation
Balsalazide inhibits cyclooxygenase
releases 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract to reduce colitis.
decreases production of arachidonic acid metabolites and inhibits prostglandin synthesis
Calendula officinalis radical scavenging activity
reduces radiation-induced expressions of monocyte chemotactic protein-1, keratinocyte-derived chemokine, granulocyte colony-stimulating factor, IL-1 alpha, and vascular endothelial growth factor (VEGF)
Efaproxiral efaproxiral works by binding and allosterically stabilizing deoxyhemoglobin in hypoxic regions of tumor
Myricetin increased Caspase-3 protein expression
free radical scavenging activity
Mentha arvensis increased the non-protein sulfhydryl (NPSH) levels, increased activity of xenobiotic enzymes
free radical scavenging activity
Target - Nucleic acids, Lipids
Drug/chemical/plant extract/supplement Mechanism
Vitamin E Free radical scavenging
Reduced radiation-induced DNA damage
Reduces lipid peroxidation
enhances immune response.
Rubia cordifolia reduces lipid peroxidation
Reduced radiation-induced DNA damage
Target - Nucleic acids, Proteins
Drug/chemical/plant extract/supplement Mechanism
Artesunate upregulated the expression of IMAA, HSUP1, FLJ11021, KIAA1904, ZRF1, SDCCAG10, LOC442573, EIF3S10, KTN1, LOC642617, LOC340089, GPR18, LOC646074, NOL8, AHNAK, GOLGA4, LOC646316, CENPF, LOC643211 and downregulated the expression of HBB, IGHG1, IGKC, HBD, IGKC, IGHA1, IGLV3-25, PLUNC, IGLV3-25, LOC652848 in vitro
Down-regulation of survivin cyclin A1, cyclin B, cyclin D1, Cdk2, Cdk4, and Cdk6 and the upregulation of p21 and p27
Induction of apoptosis, cell cycle arrest, and a hampered DNA damage response
Andrographolide Free radical scavenging
Reduces radiation-induced double-strand DNA damage
Down-regulation of Akt and NF-kB
Increases Bax and Cleaved-Caspase3 and decrease Bcl-2 expression, NF-kB levels in ECA109 cells in vitro
Induction of G0/G1 arrest
Increase in radiation-induced apoptosis and autophagy in tumor cells
Captopril Free radical scavenging
Reduces radiation-induced strand DNA damage in plasmid
lowers radiation-induced protein expression erythropoietin production
Geriforte Free radical scavenging
antioxidant property, up-regulation of detoxifying enzymes, metal chelation, reduction in the radiation-induced damage to cellular DNA, increase in endogenous GSH levels
Methotrexate disrupts DNA synthesis
Combined treatment of radiation and methotrexate induced caspase activation. and inhibited IkBα degradation in Nasal NK/T-cell lymphoma cells line
Mentat free radical scavenging activity
reduction in the radiation-induced damage to the cellular DNA, enhanced intracellular GSH levels
Nicotinamide inhibits PARP-1 enzyme which plays role in DNA repair
In combination with carbogen or normobaric oxygen, increases the tumor blood supply hence minimizes tumour hypoxia
ON01210.Na protects against radiation-induced DNA damage
Ex-Rad lowered radiation-induced level of p53 expression
enhancement of repair of DNA damage
prevention of radiation-induced apoptosis
AEOL - 10150 Mimics superoxide dismutase and catalase
Reduces tissue hypoxia and inflammation
Reduces radiation-induced enhancement of intratumoral HIF-1 and up-regulation of IL-4 and in plasma TGF-β1 levels
Reduces radiation-induced DNA oxidation
Hoechst 33342 Free radical scavenging
Reduced radiation-induced DNA damage, inhibited DNA repair
reversed radiation-induced levels of Mn-SOD and catalase, cytochrome c oxidase subunit 1
Hypericum perforatum reversed radiation-induced alterations in superoxide dismutase, catalase in wheat seedlings
Reduced radiation-induced chromosomal damage
Sanazole increased radiation-induced internucleosomal fragmentation in the nucear genome of tumor cells
reversed radiation-induced alterations in γ-Glutamyl transpeptidase and Acetylcholine esterase activity, caspase-3 activity
Troxerutin protection against gamma-radiation-induced micronuclei formation and DNA strand breaks
increased radiation-induced reduction in the activity of various antioxidant enzymes, such as superoxide dismutase
Target - Proteins, Lipids
Drug/chemical/plant extract/supplement Mechanism
Abana Free radical scavenging
Increases level of GSH
Reduces lipid peroxidation
Aloe vera extract Free radical scavenging
Increases level of GSH, TGF-β-1 and bFGF, SOD, CAT, GPx, acid phosphtase and alkaline phosphatase activity
Reduces lipid peroxidation
Asparagus racemosus extract Free radical scavenging
Increases level of superoxide dismutase, reduced glutathione and catalase
Reduces lipid peroxidation
Amaranthus paniculatus extract Free radical scavenging
Increases level of GSH, decreases acid phosphatase and alkaline phosphatase activity
Reduces lipid peroxidation
Chlorophyllin Free radical scavenging
protected superoxide dismutase, GSH, succinate dehydrogenase, cytochrome c oxidase against radiation-induced damage
Reduces lipid peroxidation
Echinacea purpurea reversed radiation-induced changes in the levels of xanthine oxidase, xanthine dehydrogenase, superoxide dismutase and catalase, glutathione peroxidase, C-reactive proteins
Reduces lipid peroxidation
Liv. 52 reduces lipid peroxidation
reversed radiation-induced levels of GSH, GSH peroxidase, GSH reductase, Glutathione s-transferase, superoxide dismutase, and catalase activity, alanine transferase, and aspartate transferase
Mentha piperata antioxidant activity
reversed radiation-induced levels of glutathione, glutathione- S-transferase, superoxide dismutase, acetylcholinestrase, and the neurotransmitters dopamine, serotonin and acetylcholine, serum erythropoeitin, acid phosphatase and alkaline phosphatase
reduces lipid peroxidation
Nardostachys jatamansi reduces lipid peroxidation
reversed radiation-induced levels of glutathione, glutathione peroxidase, catalase, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transferase activities, superoxide dismutase
free radical scavenging activity
Piper longum reduces lipid peroxidation
reversed radiation-induced levels of glutathione pyruvate transaminase, alkaline phosphatase, α-esterase
free radical scavenging activity
Sodium selenite reduces lipid peroxidation
reversed radiation-induced levels of glutathione peroxidase 1 (GPx-1) ,cleaved PARP protein, glutathione level, and glutathione peroxidase activity, cytochrome c and caspase 3 expressions
Target - Nucleic acid, Lipids, Proteins
Drug/chemical/plant extract/supplement Mechanism
Aphanamixis polystachya extract Free radical scavenging in normal cells.
Reduced level of GSH, glutathione peroxidase, glutathione-s-transferase, superoxide dismutase and catalase in tumor cells
Increases lipid peroxidationin tumor cells
Reduction in the frequencies of aberrant cells and chromosomal aberrations in normal tissues
Alpha-lipoic acid Free radical scavenging
Increases level of GSH, glutathione reductase, superoxide dismutase and catalase
Reduces radiation-induced TGF-β1 expression, phosphorylated nuclear factor kappa B and matrix metalloproteinase-9 and mitogen-activated protein kinases
Reduces lipid peroxidation
Reduction in radiarion-induced DNA damage
Ascorbic acid Free radical scavenging
Promotes chemical repair of radiation-induced DNA damage
Reduces lipid peroxidation
Restores BCL-2 expression in irradiated HL60 myeloid leukemia cells in vitro
Acorus calamus extract Free radical scavenging
Accelerates chemical repair of radiation-induced DNA damage
Reduces radiation-induced DNA damage
Reduces lipid peroxidation
Increases levels of GSH, superoxide dismutase, catalase, glutathione peroxidase
Allium sativum extract Free radical scavenging and antioxidant activity
Reduces radiation-induced DNA damage and chromosomal damage
Reduces lipid peroxidation
Increases levels of GSH, superoxide dismutase, catalase, glutathione peroxidase
Andrographis paniculata extract Free radical scavenging and antioxidant activity
Reduces radiation-induced plasmid strand breaks
Reduces lipid peroxidation
Increases levels of GSH, alkaline phosphatase and Glutamate Pyruvate Transaminase, superoxide dismutase, catalase, glutathione peroxidase, GSH, NADPH cytochrome c reductase, glutathione-s-transferase
stimulation of immune system
Adhatoda vasica extract Free radical scavenging
Reduces radiation-induced chromosomal aberrations
Reduces lipid peroxidation
Increases GSH content, SOD and catalase, decreases in acid phosphatase and increase in level of alkaline phosphatase
Alstonia scholaris extract Free radical scavenging
Reduces radiation-induced chromosomal aberrations and micronuclei induction
Reduces lipid peroxidation
Increases GSH content, SOD and catalase, decreases in acid phosphatase and increase in level of alkaline phosphatase
Aegle marmelos extract Free radical scavenging
Reduces radiation-induced DNA damage and micronuclei induction
Reduces lipid peroxidation
modulates the activity of enzymic and nonenzymic antioxidants in animal models
Increases GSH content, glutathione S-transferase, DT-diaphorase, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, hemoglobin
Brassica compestris extract reduces radiation-induced chromosomal damage
radiation-induced decline in GSH, Glutathione S-transferase, DT-diaphorase, superoxide dismutase, Glyoxalase I
reduces lipid peroxidation
Chlorpromazine increases radiation-induced micronuclei formation
Inhibited delayed plating repair of potentially lethal damage
increases radiation-induced lipid peroxidation and induces changes in membrane fluidity
depletes SH-rich molecules
Centella asiatica radical scavenging activity
reduces lipid peroxidation
reversed radiation-induced changes in glutathione, hemoglobin, Glutathione peroxidase and superoxide dismutase levels
protected against radiation-induced DNA damage
Curcumin Combination of curcumin and irradiation affected expression of p21, Bax and E2F1 proteins in PC-3 cells
reduces lipid peroxidation
protected against radiation-induced DNA damage
Dieckol & Eckol protected against radiation-induced DNA damage
reduces lipid peroxidation
free radical scavenging activity
Dieckol restored the radiation-related decline in level of Mn-sueroxide dismutase in mice
Dieckol corrected radiation-induced suppression of anti-apoptotic Bcl-2 and reduced expression of pro-apoptotic p53 and Bax
eckol treatment reduced the expression of bax, the activation of caspase 9 and caspase 3, which were induced by radiation. eckol recovered the expression of bcl-2 and mitochondrial cytochrome c which were decreased by radiation in vitro
Diltiazem inhibits glutathione depletion, decreases lipid peroxidation and increases the erythropoietin level
free radical scavenging activity
protection against radiation-induced chromosomal damage
Emblica officinalis protects against DNA strand breaks in vitro
reversed radiation-induced changes in levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione content and glutathione-S-transferase, acid and alkaline phosphatase
reduced lipid proxidation
free radical scavenging activity
Edavarone reversed radiation-induced changes in reduced glutathione levels ,superoxide dismutase and glutathione peroxidase, catalase, myeloperoxidase, levels of cleaved PARP
free radical scavenging activity
protection against radiation-induced DNA damage
Ferulic acid reversed radiation-induced levels of superoxide dismutase, catalase, GSH, ALP, SGPT, SGOT, caspase-3, caspase-9 activity,level of p-ERK , glutathione peroxidase
free radical scavenging activity
protection against radiation-induced DNA damage
reduces lipid peroxidation
Gallic acid reversed radiation-induced levels of GSH, glutathione peroxidase
enhanced DNA repair
protection against radiation-induced DNA damage
reduces lipid peroxidation
Genistein increased p21WAF1/Cip1 and decreased cyclin B1 expression, NF-κB activity, increased cleaved PARP protein
free radical scavengong activity
reduced lipid peroxidation
protection against radiation-induced DNA fragmentation
Glutathione protected succinic hydrogenase, cytochrome oxidase, glucose-6-phosphate dehydrogenase
enhnaces DNA repair
protection against radiation-induced chromosomal damage
Hesperidin reduces radiation-induced DNA damage
reversed radiation-induced levels of catalase, GSH, glutathione peroxidase, superoxide dismutase, albumin
reduces lipid peroxidation
free radical scavenging activity
Lycopene reduces radiation-induced DNA damage
reversed radiation-induced levels of alanine aminotransferase , aspartate aminotransferase, alkaline phosphatase and gamma glutamyl transferase activity, GSH and superoxide dismutase
reduces lipid peroxidation
free radical scavenging activity
Melatonin reversed radiation-induced levels of proapoptotic-p53, Bax, antiapoptotic-Bcl-xL proteins, superoxide dismutase, glutathione peroxidase, myeloperoxidase
reduces lipid peroxidation
protection against radiation-induced DNA damage
free radical scavenging activity
Morin reduces radiation-induced DNA damage
reversed radiation-induced levels of GSH, GST, superoxide dismutase, catalase, Bax, phospho Bcl-2, active caspase 9 and caspase 3
reduces lipid peroxidation
2-mercaptopropionylglycine reduces radiation-induced strand damage
reversed radiation-induced levels of TNF protein, iNOS protein and SOD activity
reduces lipid peroxidation
Moringa oleifera reduces radiation-induced chromosomal damage
reversed radiation-induced levels of superoxide dismutase, catalase and glutathionealanine aminotransferase and aspartate aminotransferase, acid and alkaline phosphatase
reduces lipid peroxidation
free radical scavenging activity
Naringin reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of GSH content, catalase, superoxide dismutase, lactose dehydrogenase, expression of p53, Bax, and Bcl-2.
Nelumbo nucifera reduces lipid peroxidation
reduces radiation-induced DNA and chromosomal damage
reversed radiation-induced levels of superoxide dismutase, catalase, glutathione peroxidase.
free radical scavenging activity
Nigella sativa reduces lipid peroxidation
reduces radiation-induced DNA and chromosomal damage
reversed radiation-induced levels of superoxide dismutase, catalase, nitric oxide synthase activity, expression of expression of Bcl-2, PD-1, Bax, and caspase-3.
free radical scavenging activity
Pilea microphylla reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of catalase, superoxide dismutase, glutathione, GST.
free radical scavenging activity
Panax ginseng reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of protein expression.
free radical scavenging activity
Podophyllum hexandrum reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of protein expression.
free radical scavenging activity
Phyllanthus amarus reduces lipid peroxidation
reduces radiation-induced DNA and chromosomal damage
reversed radiation-induced levels of superoxide dismutase, catalase , glutathione-S-transferase, glutathione peroxidase, and glutathione reductase.
free radical scavenging activity
Quercetin reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of superoxide dismutase, glutathione-peroxidase, catalase, GSH content, Glutathione-s-transferase.
free radical scavenging activity
Rutin reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of superoxide dismutase, glutathione-peroxidase, catalase, GSH content, Glutathione-s-transferase,ALP, AST and ALT, SGOT, SGPT.
free radical scavenging activity
Resveratrol reduces lipid peroxidation
enhances radiation-induced DNA damage
reversed radiation-induced levels of proteins.
free radical scavenging activity
Rosmarinus officinalis reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of hemoglobin, glutathione, catalase, acid and alkaline phosphatase.
free radical scavenging activity
Syzygium cumini reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of GSH level and activity of GST, SOD and CAT.
Sesamol reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of GSH, glutathione-s-transferase, catalase, superoxide dismutase, glutathione peroxidase.
free radical scavenging activity
Silymarin reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of glutathione reductase, catalase and glutathione peroxidase activities, serum alanine and aspartate aminotransferase as well as gamma glutamyl transpeptidase.
free radical scavenging activity
Thymol reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of GSH, GST, catalase, superoxide dismutase.
free radical scavenging activity
Tempol reduces lipid peroxidation
reduces radiation-induced DNA and chromosomal damage
reversed radiation-induced levels of glutathione peroxidase, glutathione, superoxide dismutase.
Tinospora cordifolia reduces lipid peroxidation, increases lipid peroxidation in tumor cells
enhances radiation-induced DNA damage in tumor
reversed radiation-induced levels of alkaline phosphatase, GSH, catalase and SOD activities, acid and alkaline phosphatase, lactate dehydrogenase, GST.
free radical scavenging activity and metal chelation property
Terminalia chebula reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of superoxide dismutase, catalase, GSH, GST, xanthine-oxidase.
free radical scavenging activity
Withania somnifera reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of superoxide dismutase, serum creatine phosphokinase , lactate dehydrogenase and asparatate amino transferase activities, creatine kinase-MB and cardiac troponin 1, catalase
free radical scavenging activity and antioxidant property
Zingiber officinale reduces lipid peroxidation
reduces radiation-induced DNA damage
reversed radiation-induced levels of superoxide dismutase, GSH, glutathione reductase, glutathione peroxidase, cholesterol-7σ-hydrxylase
free radical scavenging activity and antioxidant property