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Syzygium cumini

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RADIOBIOLOGICAL ASPECTS

Dose
Modification
Ratio[DMF]:
Studies
related
to DMF :
Test System Dose of radiation Extract Conc. Time of extract administration DMF/qualitative
radiomodification
Reference
Swiss albino mice and mice bearing fibrosarcoma 3, 6 and 9 Gy hydroalcoholic seed extract, 100 mg/kg b. wt./day, orally once daily for 5 consecutive days before irradiation protection of liver, spleen and intestine from radiation-induced damage [1]
peripheral blood leucocytes in vitro from irradiated mice gamma irradiation protection of DNA from radiation damage
60Co irradiation
Male Swiss albino mice 6, 7, 8, 9, 10 and 11 Gy
1.66 Gy/min
hydroalcoholic extract of seeds, 80 mg/kg body wt., IP, once daily, for 5 consecutive days before irradiation
irradiation on the 5th day
DRF(survival LD50/30) = 1.24
reduction in symptoms of radiation sickness
[2]
Male Swiss albino mice 0.5 Gy
1.66 Gy/min
leaf extract, 50 mg/kg body weight, orally, once daily, for 5 consecutive days last administration is performed one hr before irradiation Reduction in radiation-induced micronuceli formation in spleen
protection factor(MN assay)=2.6
[3]
1 Gy protection factor(MN assay)=2.0
2 Gy protection factor(MN assay)=1.8
3 Gy protection factor(MN assay)=1.6
4 Gy protection factor(MN assay)=1.6
human peripheral blood lymphocytes 3 Gy
1.16 Gy/min
leaf extract, 12.5 µg/ml before irradiation decline in the radiation-induced micronuclei-induction [4]
Male Swiss albino mice 10 Gy
1.16 Gy/min
leaf extract, 30 mg/kg b.wt, IP, consecutively for 5 days on the 5th day, the last administration was performed one hr before irradiation Reduction in radiation-induced sickness and mortality
increased survival
[5]
leaf extract, 20, 30, 40 mg/kg b.wt, IP, consecutively for 5 days protection against radiation-induced gastrointestinal death
leaf extract, 10-60 mg/kg b.wt, IP, consecutively for 5 days protection against radiation-induced bone marrow death
Male Swiss albino mice 7, 10 or 15 Gy
1.16 Gy/min
leaf extract, 50 mg/kg body weight, orally once daily for 5 consecutive days on the 5th day, the last administration was performed one hr before irradiation protection against the radiation-induced damage in the small intestine [6]
Fractionation study:
REFERENCES
1. Sharma A, Soyal D, Goyal PK, Radioprotection by seed extract of Syzygium cumini in normal tissues of fibrosarcoma bearing mice. Indian Society for Radiation Biology, Delhi (India); K.S. Hegde Medical Academy, Mangalore (India); 90 p; Oct 2013; p. 61; ICRB-2013: international conference on radiation biology and clinical applications; Mangalore (India); 25-27 Oct 2013.
https://inis.iaea.org/search/search.aspx?orig_q=RN:45108336
2. Jagetia GC, Baliga MS, Venkatesh P, Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of γ -radiation. J. Radiat. Res. 2005; 46(1): 59–65.
http://dx.doi.org/10.1269/jrr.46.59
3. Jagetia GC, Shetty PC, Vidyasagar MS, Inhibition of radiation-induced DNA damage by Jamun, Syzygium cumini, in the cultured splenocytes of mice exposed to different doses of γ-radiation. Integrative Cancer Therapies. 2012; 11(2): 141– 153.
http://dx.doi.org/10.1177/1534735411413261
4. Jagetia GC, Baliga MS, Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicology Letters. 2002; 132(1) : 19–25.
http://dx.doi.org/10.1016/S0378-4274(02)00032-2
5. Jagetia GC, Baliga MS, Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation. Nahrung/Food. 2003;47(3):181 – 185.
http://dx.doi.org/10.1002/food.200390042
6. Jagetia GC, Shetty PC, Vidyasagar MS, Treatment of mice with leaf extract of jamun(Syzygium cumini Linn. Skeels)protects against the radiation-induced damage in the intestinal mucosa of mice exposed to different doses of γ-radiation. Pharmacologyonline. 2008; 1: 169-195.
http://pharmacologyonline.silae.it/files/archives/2008/vol1/18_Ganesh.pdf