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"Radiosensitisers and Radioprotectors"

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Rubia cordifolia

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RADIOBIOLOGICAL ASPECTS

Dose
Modification
Ratio[DMF]:
Studies
related
to DMF :
aqueous extract of Rubia cordifolia roots( ~50 µg/ml) significantly prevented rat liver mitochondrial damage induced by ionizing radiation. Single strand breaks induced in plasmid pBR322 DNA following ionizing radiations was effectively prevented by root extract[1]

Test System Dose of radiation Extract Conc. Time of extract administration DMF/qualitative
radiomodification
Reference
60Co irradiation
plasmid pBR322 0-25 Gy
1.88 Gy/min
hydroalcoholic root extract, 0-10 mg/ml before irradiation DMF(at 50% protection) = 1.38 [2]
Mouse splenocyte and thymocyte in vitro 0 Gy-50 Gy
1.88 Gy/min
hydroalcoholic root extract, 200 mg/ml before irradiation protection against radiation-induced cell death [2]
Peripheral leucocytes ex vivo from human volunteers 4 Gy
1.88 Gy/min
hydroalcoholic root extract, 10 mg/ml before irradiation protection against radiation-induced DNA damage [2]
Male Swiss Albino mice 4 Gy
1.88 Gy/min
hydroalcoholic root extract, 200 mg/kg bw, orally protection against radiation-induced DNA damage in spleen and bone marrow cells [2]
Male Swiss Albino mice 10 Gy
1.88 Gy/min
hydroalcoholic root extract, 200 mg/kg bw, orally, for 7 consecutive days 1 hr before irradiation protection against radiation-induced mortality [2]
Male Swiss Albino mice 10 Gy
2.5 Gy/min
alcoholic root extract, 115, 230 and 460 mg/kg body weight, IP 90 mins before irradiation protection against radiation-induced mortality and lipid peroxidation [3]
5 and 7.5 Gy alcoholic root extract, 460 mg/kg body weight, IP protection of endogenous colony forming units
2 Gy alcoholic root extract, 460 mg/kg body weight, IP protection against radiation-induced micronuclei formation
Fractionation study:
REFERENCES
1. Kamat JP, Mishra, KP, Radioprotection by Rubia cordifolia: studies on mitochondrial membranes. Sixteenth annual conference of Indian Nuclear Society: science behind nuclear technology. Mumbai (India)Íž 15-18 Nov 2005.
https://inis.iaea.org/search/search.aspx?orig_q=RN:37061834
2. Chapter 5 : Radioprotective, nephoprotective and anti-inflammatory activities of the plant Rubia cordifolia Linn. ; In : Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance, a thesis by Joy J, Guide : Nair CKK, submitted to Mahatma Gandhi University, Amala Cancer Research Center, India, 2014.
http://shodhganga.inflibnet.ac.in/handle/10603/25801
3. Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology 2007; 45(7):620-625.
http://nopr.niscair.res.in/bitstream/123456789/5335/1/IJEB%2045(7)%20620-625.pdf