Welcome to University of Mumbai, Department of Biophysics


Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

Alphabetical Search   >  N   >  Nelumbo nucifera                                                                                                                                                                 Top

Nelumbo nucifera

Go To:


General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


RADIOBIOLOGICAL ASPECTS

Dose
Modification
Ratio[DMF]:
Studies
related
to DMF :
Test System Dose of radiation Extract Conc. Time of extract administration DMF/qualitative
radiomodification
Reference
60Co irradiation
male Swiss albino mice 8 and 10 Gy
1.14 Gy/min
acetone–water extract of Nelumbo nucifera Gaertn, 200 mg/kg, daily, intragastric, for 15 consecutive days before irradiation DMF(survival) = 1.18
protection against radiation-induced skin damage
[1]
4 Gy protection against radiation-induced lipid peroxidation, enzyme and DNA damage
8 Gy protection against radiation-induced damage to spleen, blood cells
Fractionation study:
REFERENCES
1. Duan Y et al, Whole body radioprotective activity of an acetone–water extract from the seedpod of Nelumbo nucifera Gaertn. seedpod. Food and Chemical Toxicology 2010;48: 3374–3384.
http://dx.doi.org/10.1016/j.fct.2010.09.008