Dose Modification Factor[DMF]: |
DMF based on LD50/30 :- 1.4 (data from mice study)[1], [2].
1.40-1.65(animal data for Thiola).
When combined with aminothiols (AET, MEA, cysteine), DRF of 1.72 could be achieved[3].
|
Studies related to DMF : |
MPG at concentration around 0.02mM and 15mM found to have slight radioprotective action. Protection was not found to increase with the increase in
concentration of MPG - A study on in vitro mouse L cells[4].
After high doses of radiation, drug became less effective in protecting the tissue[5],[6].
In mouse erythrocytes, MPG did not have any effect on the initial cell depression, but it afforded significant protection at later intervals with
sublethal gamma doses (250 R and 500 R); however, after lethal exposure (1000 R) the drug did not show any protective effect [7].
MPG offered protection to mouse liver after whole-body irradiation with 1000 R gamma rays[8] and with 500 R gamma rays to mouse
testes both at initial stage of cell damage as well as at the later stage of recovery[9].
At high concentrations of MPG, enhancement of lipid peroxidation was observed instead of reduction following gamma-irradiation at 266.4Gy
[10]. A study with MPG has also revealed its radiosensitizing ability under particular circumstances[11].
Decrease in effectiveness of radioprotection by MPG may be contributed to the availability of quantity other than optimum for radioprotection
in particular tissue, also to metabolism of MPG to its oxide, disulfide and other derivatives after its administrations [12].
Dose dependent protective effect of 2-MPG on radiation induced mitotic delay in cultures mammalian cell (L-5) is observed [13].
It has been established that this drug, as the Sodium salt, is able to prevent all radiation damage in animals irradiated with lethal or supra
lethal doses of various radiation qualities, if applied not only before but within 3-5 h after irradiation[14]
The protection by MPG in mice against lethal IR doses could last at least for more than 3 hours after a intraperitoneal injection[1],[2]
MPG, when given 30 minutes after exposure, was not found to be so effective in radioprotection[15]
|
Protection offered by MPG at different parameters |
60Co-irradiation
Dose of radiation |
Drug Dose |
Time of administration of drug |
DMF |
Reference |
1.5 Gy, 3 Gy, 6 Gy, 9 Gy |
|
before irradiation |
|
[6] |
1000R in 42 minutes |
20 mg/kg, IP |
15-30 mins before irradiation |
|
[8] |
1000R in 42 minutes |
20 mg/kg, IP |
30 mins before irradiation |
|
[16] |
1000R(25 R/min) |
|
15-30 mins before irradiation |
|
[17] |
36 R/min |
0.5 mg, 1mg |
15 mins before irradiation |
1.4 |
[1] |
1000 R |
0.01mg to 1mg |
30 mins before irradiation |
max protection at 0.5 mg |
[1] |
0.6, 1.2, 2.4 Gy |
|
before irradiation |
|
[18],[19] |
250 R |
|
before irradiation |
|
[20] |
2.2 Gy(sublethal) |
20 mg/kg, IP |
before irradiation |
|
[21] |
0.6, 1.2 Gy |
|
before irradiation |
|
[22] |
150 R |
|
before irradiation |
|
[23],[24] |
50R, 150R, 250R |
|
before irradiation |
|
[25] |
1500R |
|
before irradiation |
|
[26] |
250R, 500R |
|
before irradiation |
|
[7] |
250R, 500R, 1000R
(50 R/min) |
20 mg/kg, IP |
15-30 mins before irradiation |
|
[27] |
1.5 Gy |
|
before irradiation |
|
[28] |
2.5Gy, 5Gy, 10 Gy |
|
before irradition |
|
[29] |
1Gy, 2Gy, 4Gy, 6Gy, 8Gy
(23.65 Gy/min)
|
0.408mg eqv. of MPG as
1m LEM(liposomal encapsulated MPG) |
30 mins before irradiation |
|
[12] |
500 R
(25 R/min) |
20 mg/kg, IP |
15-30 mins before irradiation |
|
[9] |
500R in 19 mins |
20mg/kg, IP |
30 mins before irradiation |
|
[15] |
500R in 19 mins |
20 mg/kg, IP |
15-30 mins after irradiation |
Not effective |
[15] |
1200R in 40 mins |
20 mg/kg,IP |
30 mins before irradiation |
|
[30] |
200R |
20-100 mM |
after irradiation |
|
[13] |
0.5 Gy, 1.5 Gy, 2.5 Gy |
|
before irradiation |
|
[31] |
0.5Gy, 1.5Gy, 3Gy
4.5Gy, 6Gy
(0.72 Gy/min) |
|
15-25 mins before irradiation |
|
[5] |
500R, 1000R, 1500R |
|
before irradiation |
|
[32] |
500R, 1000R, 1500R
(24 R/min) |
|
15-30 mins before irradiation |
|
[33] |
80-160Gy (40.22 Gy/min) |
0.2 mg/ml, 0.5 mg/ml |
before irradiation |
|
[34] |
2.5Gy, 5Gy, 10Gy
(0.5 Gy/min) |
20 mg/kg, IP |
15-30 mins before irradiation |
|
[35] |
0.5Gy, 1Gy, 2Gy
(0.5 Gy/min) |
20 mg/kg |
15-20 mins before irradiation |
|
[36] |
1000R |
10, 20 and 200 mg/kg |
15 mins before irradiation |
|
[2] |
0.5Gy, 1.5Gy, 3Gy,
4.5Gy, 6 Gy
(0.72 Gy/min) |
20 mg/kg, IP |
15-20 mins before irradiation |
protection at low doses(0.5 Gy, 1.5 Gy) |
[5] |
39 Gy |
10 mM |
10 mins before irradiation
(in oxygen) |
1.30 |
[37] |
39 Gy |
10 mM |
25 mins before irradiation
(in oxygen) |
1.16 |
[37] |
39 Gy |
10 mM |
10 mins before irradiation
(in anorexia) |
1.21 |
[37] |
39 Gy |
10 mM |
25 mins before irradiation
(in anorexia) |
0.89 |
[37] |
39 Gy |
20 mM |
10 mins before irradiation
(in oxygen) |
1.27 |
[37] |
39 Gy |
20 mM |
25 mins before irradiation
(in oxygen) |
1.10 |
[37] |
39 Gy |
20 mM |
10 mins before irradiation
(in anorexia) |
1.57 |
[37] |
39 Gy |
20 mM |
25 mins before irradiation
(in anorexia) |
0.97 |
[37] |
900 rads |
|
4 hrs before irradiation or
24 hrs after irradiation |
moderate radioprotection |
[38] |
X-irradiation
Dose of radiation |
Drug Dose |
Time of administration of drug |
DMF |
Reference |
500R
(75 R/min) |
0.02 mM and 15 mM |
15 mins before irradiation |
|
[4] |
10 Gy |
20 mg/kg, IP |
1 day after irradiation |
|
[39] |
3Gy, 19Gy |
|
before irradiation |
|
[40] |
7.60 Gy
(LD50/30) |
20 mg/kg |
before irradiation |
1.1 |
[41] |
500R |
0.01-0.1 mM and 5-60 mM |
before irradiation |
|
[2] |
Beta-irradiation from Tritiated water(HTO)
Dose of radiation |
Drug Dose |
Time of administration of drug |
DMF |
Reference |
IP injection of 5microCi/g of HTO |
20 mg/kg |
15-30 mins before injection of HTO |
|
[42] |
|
Fractionation study: |
Cervical cancer patients receiving conventional fractionation radiotherapy (whole pelvis irradiation; a daily dose of 150 rad, 5 times per week,
the total tumor dose being about 6000 rad in the case of radiotherapy alone, or 4050 rad in postoperative cases) as well as MPG 250 mg intravenously
15-30 min before every irradiation, showed statistically significant increase in the leukocyte counts and decrease in chromosome and aberration yields
than control group [2].
|
Radiation source: |
60Co- gamma rays [5], [22], [43].
Many animal Studies are reported against sublethal, lethal and supralethal doses of x-ray, gamma and mixed neutron-gamma radiation from an
atomic reactor[3].
Beta radiation from tritiated water[42].
UV-radiation[44].
|
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|