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Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

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Rubia cordifolia

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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PHARMACOLOGICAL ASPECTS

Half-life:
levels in
cells/tissues
/organs
Serum/Plasma
level:
Serum/Plasma
constituents/
protein binding
:
Uptake/
Distribution
:
Diffusion in tumor:
Pathway:
Biotrans-
formation
Location:
metabolites:
enzymes
associated
with
metabolism
Effect on Enzymes
(non-target),
protein levels/
influence on
receptors:
The alcoholic extract of R. cordifolia has been shown to significantly inhibit potato lipoxygenase[1]
Rubia cordifolia elevated expression of γ-glutamylcysteine ligase in rat hippocampal slices[2]
mollugin isolated from Rubia cordifolia caused inhibition of CYP1A2 in human liver microsomes.[3]
Transporters
/Carriers:
Route of
Elimination:
Excretion
/Clearance:
Pharmaco-
dynamics:
REFERENCES:
1. Tripathi YB et al, Rubia cordifolia inhibits potatolipoxygenases. Indian Journal of Experimental Biology. 1995; 33(2): 109-112.
http://eurekamag.com/research/002/690/002690269.php
2. Rawal A, Muddeshwar M, Biswas S, Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygenglucose deprivation in rat hippocampal slices. Biochemical and Biophysical Research Communications 2004; 324(2):588–596.
http://dx.doi.org/10.1016/j.bbrc.2004.09.094
3. Kim H et al, Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes. Food Chem Toxicol. 2013;51:33-7.
http://dx.doi.org/10.1016/j.fct.2012.09.013