| Name: |
Withania somnifera |
|---|
| Synonyms/Scientific names: |
Withania somnifera(L.) Dunal[1]
Synonyms/common names :
ashwagandha, Indian ginseng, and winter
cherry[2],[3],[4]
Trade name:
|
|---|
| Description: |
Family : Solanaceae[1],[4]
|
| Extract used: |
Alcoholic root extract has been used for radiomodification study[5]
|
| Phyto-constituents(active): |
Leaves
withanolides E-M [6]
27-hydroxy withanone, 17-hydroxy withaferin A, 17-hydroxy-27-deoxy withaferin A, withaferin A, withanolide D, 27-hydroxy withanolide B, withanolide A, withanone and 27-deoxywithaferin A[7]
Roots
β-sitosterol, stigmasterol, β-sitosterol glucoside, stigmasterol glucoside, α + β glucose [8]
27-hydroxy withanone, 17-hydroxy withaferin A, 17-hydroxy-27-deoxy withaferin A, withaferin A, withanolide D, 27-hydroxy withanolide B, withanolide A, withanone and 27-deoxywithaferin A[7]
|
| Actions & Indications: |
Pharmcological Action-
cardioprotective in rats[9]
hepatoprotective and antioxidant in rats[10]
immunostimulatory in mice[11]
Therapeutic indications:
Preclinical study-
|
| Notes: |
|
| REFERENCES |
| 1. |
Chapter 15 : Use of Ayurvedic Medicinal Plants as Immunomodulators in Geriatrics : Preclinical studies by Bhat HP et al; In :Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, edited by Watson RR, Academic Press, 2015, page no. 145.
https://books.google.com/books?id=fNacBAAAQBAJ&pg=PA145 |
| 2. |
Monograph : Withania somnifera. Alternative Medicine Review 2004;9(2) :211-214.
http://www.altmedrev.com/publications/9/2/211.pdf |
| 3. |
45 : Medical Efficacy of Indian Herbal Remedies for the Treatment of Arthritis by Arora R et al; In :Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, edited by Watson RR, Preedy VR, Academic Press, 2013, Page no. 612.
https://books.google.com/books?id=VyyGSO-orYwC&pg=PA612 |
| 4. |
Ashwagandha : Herb Monographs ; In : Herbal Therapy and Supplements: A Scientific and Traditional Approach by Kuhn MA, Winston D, Lippincott Williams & Wilkins, 2000, Page no. 37
https://books.google.com/books?id=puxU3qzD5_YC&pg=PA37 |
| 5. |
Devi PU, Sharada AC, Solomon FE, Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha)
on a transplantable mouse tumor, Sarcoma180. Indian J Exp Biol. 1993 ;31(7):607-11.
http://www.ncbi.nlm.nih.gov/pubmed/8225418 |
| 6. |
Glotter E et al, Constituents of Withania
somnifera Dun—XIII : The
withanolides of chemotype III. Tetrahedron
1973;29(10):1353-1364.
http://dx.doi.org/10.1016/S0040-4020(01)83156-2 |
| 7. |
Chaurasiya ND et al, Analysis of withanolides in root and leaf of Withania somnifera by HPLC with
photodiode array and evaporative light scattering detection. Phytochem Anal. 2008;19(
2):148-54.
http://dx.doi.org/10.1002/pca.1029 |
| 8. |
Misra L et al, Withanolides from Withania somnifera roots. Phytochemistry
2008;69(4):1000–1004.
http://dx.doi.org/10.1016/j.phytochem.2007.10.024 |
| 9. |
Mohanty I et al, Mechanisms of cardioprotective effect of Withania somnifera in experimentally
induced myocardial infarction. Basic Clin Pharmacol Toxicol. 2004;94(4):184-90.
http://dx.doi.org/10.1111/j.17427843.2004.pto940405.x |
| 10. |
Sabina EP et al, Hepatoprotective and antioxidaant potential of Withania somnifera against Paracetamol-induced liver damage in rats. International Journal of Pharmacy and Pharmaceutical Sciences 2013;5(Suppl 2):648-651.
http://www.ijppsjournal.com/Vol5Suppl2/6783.pdf |
| 11. |
Ziauddin M et al, Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. 1996;50(2):69-76.
http://www.ncbi.nlm.nih.gov/pubmed/8866726 |
