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Withania somnifera

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GENERAL FEATURES

Name: Withania somnifera
Synonyms/Scientific names: Withania somnifera(L.) Dunal[1]
Synonyms/common names :
ashwagandha, Indian ginseng, and winter cherry[2],[3],[4]
Trade name:
Description: Family : Solanaceae[1],[4]
Extract used: Alcoholic root extract has been used for radiomodification study[5]
Phyto-constituents
(active):
Leaves
withanolides E-M [6]
27-hydroxy withanone, 17-hydroxy withaferin A, 17-hydroxy-27-deoxy withaferin A, withaferin A, withanolide D, 27-hydroxy withanolide B, withanolide A, withanone and 27-deoxywithaferin A[7]
Roots
β-sitosterol, stigmasterol, β-sitosterol glucoside, stigmasterol glucoside, α + β glucose [8]
27-hydroxy withanone, 17-hydroxy withaferin A, 17-hydroxy-27-deoxy withaferin A, withaferin A, withanolide D, 27-hydroxy withanolide B, withanolide A, withanone and 27-deoxywithaferin A[7]
Actions
& Indications:
Pharmcological Action-
cardioprotective in rats[9]
hepatoprotective and antioxidant in rats[10]
immunostimulatory in mice[11]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Chapter 15 : Use of Ayurvedic Medicinal Plants as Immunomodulators in Geriatrics : Preclinical studies by Bhat HP et al; In :Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, edited by Watson RR, Academic Press, 2015, page no. 145.
https://books.google.com/books?id=fNacBAAAQBAJ&pg=PA145
2. Monograph : Withania somnifera. Alternative Medicine Review 2004;9(2) :211-214.
http://www.altmedrev.com/publications/9/2/211.pdf
3. 45 : Medical Efficacy of Indian Herbal Remedies for the Treatment of Arthritis by Arora R et al; In :Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, edited by Watson RR, Preedy VR, Academic Press, 2013, Page no. 612.
https://books.google.com/books?id=VyyGSO-orYwC&pg=PA612
4. Ashwagandha : Herb Monographs ; In : Herbal Therapy and Supplements: A Scientific and Traditional Approach by Kuhn MA, Winston D, Lippincott Williams & Wilkins, 2000, Page no. 37
https://books.google.com/books?id=puxU3qzD5_YC&pg=PA37
5. Devi PU, Sharada AC, Solomon FE, Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma180. Indian J Exp Biol. 1993 ;31(7):607-11.
http://www.ncbi.nlm.nih.gov/pubmed/8225418
6. Glotter E et al, Constituents of Withania somnifera Dun—XIII : The withanolides of chemotype III. Tetrahedron 1973;29(10):1353-1364.
http://dx.doi.org/10.1016/S0040-4020(01)83156-2
7. Chaurasiya ND et al, Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection. Phytochem Anal. 2008;19( 2):148-54.
http://dx.doi.org/10.1002/pca.1029
8. Misra L et al, Withanolides from Withania somnifera roots. Phytochemistry 2008;69(4):1000–1004.
http://dx.doi.org/10.1016/j.phytochem.2007.10.024
9. Mohanty I et al, Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol. 2004;94(4):184-90.
http://dx.doi.org/10.1111/j.17427843.2004.pto940405.x
10. Sabina EP et al, Hepatoprotective and antioxidaant potential of Withania somnifera against Paracetamol-induced liver damage in rats. International Journal of Pharmacy and Pharmaceutical Sciences 2013;5(Suppl 2):648-651.
http://www.ijppsjournal.com/Vol5Suppl2/6783.pdf
11. Ziauddin M et al, Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. 1996;50(2):69-76.
http://www.ncbi.nlm.nih.gov/pubmed/8866726