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Troxerutin

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GENERAL FEATURES

Name: Troxerutin
Synonyms: Trioxyethylrutine[1]
Trade name: Venoruton; Venoruton Forte; Troxerutin[1]
Chemical name: 3',4',7-tri-O-(beta-hydroxy-ethyl)-rutoside[2]
Flavone, 3,5-dihydroxy-3',4',7-tris(2-hydroxyethoxy)-, 3-(6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside)[1]
{2-[3,4-bis(2- hydroxyethoxy)phenyl]-3[(6-deoxy-α-L-mannopyranosyl)- β(-D-glucopyranosyl)-oxy]-5-hydroxy- 7-(2hydroxyethoxy)-4H-1-benzo-pyran-4-one}[3]
Molecular Weight:
Source:
Structure: [5],[4],[3]
Chemical Nature: Troxerutin is a trihydroxyethylated derivative of the natural bioflavonoid rutin.[6]
Actions
& Indications:
Pharmcological Action-
hepatoprotective in mice[7],[6]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Troxerutin; In : Pharmaceutical Manufacturing Encyclopedia, 3rd Edition, William Andrew Publishing, Elsevier, 2013, page no. 3371.
https://books.google.co.in/books?id=_J2ti4EkYpkC&pg=PA3371
2. Dittrich P et al, HPLC determination of troxerutin in plasma and urine following oral administration in man. Arzneimittelforschung. 1985;35(4):765-7.
https://www.ncbi.nlm.nih.gov/pubmed/4015744
3. Ping X et al, Radioprotective effects of troxerutin against gamma irradiation in V79 cells and mice. Asian Pac J Cancer Prev. 2011;12(10):2593-6.
https://www.ncbi.nlm.nih.gov/pubmed/22320937
4. Maurya DK, Salvi VP, Nair CKK, Radioprotection of normal tissues in tumor-bearing mice by troxerutin. J Radiat Res. 2004;45(2):221-8.
http://dx.doi.org/10.1269/jrr.45.221
5. Chapter 1. Application of NMR spectroscopy in plant polyphenols associated with human health by Ziaullah, Rupasinghe V; In : Applications of NMR Spectroscopy:, Volume 2, edited by Atta-ur-Rahman, Choudhary MI, Elsevier, 2015, page no. 28.
https://books.google.co.in/books?id=0KG4CgAAQBAJ&pg=PA28
6. Zhang ZF et al, Troxerutin protects against 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion. J Hazard Mater. 2015;283:98-109.
http://dx.doi.org/10.1016/j.jhazmat.2014.09.012
7. Zhang ZF et al, Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose. J Agric Food Chem. 2009;57(17):7731-6.
http://dx.doi.org/10.1021/jf9012357