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Thymol

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GENERAL FEATURES

Name: Thymol
Synonyms: 3-p-Cymenol, alpha-Cymophenol, 3-Hydroxy p-cymene, 3-Methyl-6-isopropylphenol, Thyme camphor[1]
2-hydroxy-1-isopropyl-4-methyl benzene[2]
2-isopropyl-5-methylphenol[3]
Trade name: preparation containing thyme extract (Bronchipret® TP tablets)[4]
Chemical name: 5-Methyl-2-(1-methylethyl)phenol[1]
Molecular Weight: 150.22 g/mol[1]
Source: It is one of the constituents of oil derived from Thyme(Thymus vulgaris L.)[5]
Structure: [2],[6]
Chemical Nature:
Actions
& Indications:
Pharmcological Action-
hepatoprotective in mice[7]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Section B. Specifications of Certain flavouring Agents ; In : Compendium of Food Additive Specifications: Addendum 8 by Food and Agriculture Organization of the United Nations, Food & Agriculture Org., 2000, page no. 170.
https://books.google.co.in/books?id=0vCbGRfCG04C&pg=PA170
2. 1. Thermochemistry by Gilbert GL et al ; In : Chemical Demonstrations: A Handbook for Teachers of Chemistry, Volume 1 by Shakhashiri BZ, Univ of Wisconsin Press, 1983, page no. 35.
https://books.google.co.in/books?id=0rx6Cjx_l-AC&pg=PA35
3. Chapter 13. Benzene and its derivatives ; In : Introduction to General, Organic and Biochemistry by Bettelheim FA et al, Cengage Learning, 2015, page no. 331.
https://books.google.co.in/books?id=wxadBQAAQBAJ&pg=PA331
4. Kohlert C et al, Systemic availability and pharmacokinetics of thymol in humans. J Clin Pharmacol. 2002;42(7):731-7.
http://dx.doi.org/10.1177/009127002401102678
5. Handbook of Arabian Medicinal Plants, by Ghazanfar SA, CRC Press, 1994, page no. 128.
https://books.google.co.in/books?id=8CATyYuAeuEC&pg=PA128
6. Archana PR et al, Thymol, a naturally occurring monocyclic dietary phenolic compound protects Chinese hamster lung fibroblasts from radiation-induced cytotoxicity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2009;680(1-2):70–77.
http://dx.doi.org/10.1016/j.mrgentox.2009.09.010
7. Alam K et al, The protective action of thymol against carbon tetrachloride hepatotoxicity in mice. Pharmacol Res. 1999 ;40(2):159-63.
http://dx.doi.org/10.1006/phrs.1999.0472