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Terminalia chebula

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GENERAL FEATURES

Name: Terminalia chebula
Synonyms/Scientific names: Terminalia chebula Retz.[1]
Synonyms/common names :
harra, Hritika, Harad[2]
Haritaki[3]
Trade name:
It is one of the constituents of an Ayurvedic Rasayana called "Triphala"[3]
Description: Family : Combretaceae[2],[1]
Extract used: Ethanol[4] and aqueous[5] extracts of fruits have been used for radioprotection study.
Phyto-constituents
(active):
Fruits:
Ellagic acid, Chebulinic acid, 2,4-chebulyl-β-D-glucopyranose[6]
ellagic acid, ascorbic acid, gallic acid[5]
Chebulinic acid, ellagic and gallic acids, ethyl gallate, and luteolin[7]
Actions
& Indications:
Pharmcological Action-
hepatoprotective in mice[8]
anti-diabetic activity in rats[9]
antipyretic in rats[10]
analgesic in humans[11]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Terminalia chebula Retz. ; In : Medicinal and Aromatic Plants of Himachal Pradesh, by Chauhan NS, Indus Publishing, 1999, page no. 410.
https://books.google.co.in/books?id=gAQnTAU-3lcC&pg=PA410
2. Proceedings of National Seminar: Land Use, Land Cover Change, Water Resource, Management, Tourism Development And Biodiversity In Madhya Pradesh, by Vishwakarma DD, Bhargava A, Namdeo GK, Educreation Publishing, Page no. 178.
https://books.google.co.in/books?id=x6LSCgAAQBAJ&pg=PA178
3. 14. Use of the Ayurvedic Drug Triphala in Medical Conditions Afflicting Older Adults by Baliga MS et al; In : Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, edited by Watson RR, Academic Press, 2015, page no. 136-137.
https://books.google.co.in/books?id=fNacBAAAQBAJ&pg=PA136
4. Dixit D et al, Radioprotective effect of Terminalia Chebula Retzius extract against gamma-irradiation-induced oxidative stress. Biomedicine & Aging Pathology 2013;3(2):83–88.
http://dx.doi.org/10.1016/j.biomag.2012.10.008
5. Naik GH et al, Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 2004;11(6):530–538.
http://dx.doi.org/10.1016/j.phymed.2003.08.001
6. Saleem A et al, Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit. J Ethnopharmacol. 2002 ;81(3):327-36.
http://dx.doi.org/10.1016/S0378-8741(02)00099-5
7. Klika KD et al, The structural and conformational analyses and antioxidant activities of chebulinic acid and its thrice-hydrolyzed derivative, 2,4-chebuloyl-β-D-glucopyranoside, isolated from the fruit of Terminalia chebula. ARKIVOC 2004; vii: 83-105.
http://www.arkat-usa.org/get-file/20031
8. Choi MK et al, Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice. Evid Based Complement Alternat Med. 2015;2015:517350.
http://dx.doi.org/10.1155/2015/517350
9. Senthilkumar GP et al, Anti-diabetic activity of fruits of Terminalia chebula on Streptozotocin induced diabetic rats. Journal of health science 2006;52(3):283-291.
http://dx.doi.org/10.1248/jhs.52.283
10. Afsar SK et al, Pharmacological evaluation of anti-pyretic activity of ethanolic fruit extract of Terminalia chebula in Wistar rats. IJAPR 2012;3(1):692-695.
http://www.ijapronline.org/admin/images/20120513_S.K.%20Afsar%20et%20al,%20IJAPR.pdf
11. Kumar CU, Pokuri VK, Pingali U, Evaluation of the analgesic activity of standardized aqueous extract of Terminalia chebula in healthy human participants using hot air pain model. J Clin Diagn Res. 2015; 9(5): FC01–FC04.
http://dx.doi.org/10.7860/JCDR/2015/11369.5916