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Terminalia chebula

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Name: Terminalia chebula
Synonyms/Scientific names: Terminalia chebula Retz.[1]
Synonyms/common names :
harra, Hritika, Harad[2]
Trade name:
It is one of the constituents of an Ayurvedic Rasayana called "Triphala"[3]
Description: Family : Combretaceae[2],[1]
Extract used: Ethanol[4] and aqueous[5] extracts of fruits have been used for radioprotection study.
Ellagic acid, Chebulinic acid, 2,4-chebulyl-β-D-glucopyranose[6]
ellagic acid, ascorbic acid, gallic acid[5]
Chebulinic acid, ellagic and gallic acids, ethyl gallate, and luteolin[7]
& Indications:
Pharmcological Action-
hepatoprotective in mice[8]
anti-diabetic activity in rats[9]
antipyretic in rats[10]
analgesic in humans[11]
Therapeutic indications:
Preclinical study-
1. Terminalia chebula Retz. ; In : Medicinal and Aromatic Plants of Himachal Pradesh, by Chauhan NS, Indus Publishing, 1999, page no. 410.
2. Proceedings of National Seminar: Land Use, Land Cover Change, Water Resource, Management, Tourism Development And Biodiversity In Madhya Pradesh, by Vishwakarma DD, Bhargava A, Namdeo GK, Educreation Publishing, Page no. 178.
3. 14. Use of the Ayurvedic Drug Triphala in Medical Conditions Afflicting Older Adults by Baliga MS et al; In : Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, edited by Watson RR, Academic Press, 2015, page no. 136-137.
4. Dixit D et al, Radioprotective effect of Terminalia Chebula Retzius extract against gamma-irradiation-induced oxidative stress. Biomedicine & Aging Pathology 2013;3(2):83–88.
5. Naik GH et al, Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 2004;11(6):530–538.
6. Saleem A et al, Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit. J Ethnopharmacol. 2002 ;81(3):327-36.
7. Klika KD et al, The structural and conformational analyses and antioxidant activities of chebulinic acid and its thrice-hydrolyzed derivative, 2,4-chebuloyl-β-D-glucopyranoside, isolated from the fruit of Terminalia chebula. ARKIVOC 2004; vii: 83-105.
8. Choi MK et al, Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice. Evid Based Complement Alternat Med. 2015;2015:517350.
9. Senthilkumar GP et al, Anti-diabetic activity of fruits of Terminalia chebula on Streptozotocin induced diabetic rats. Journal of health science 2006;52(3):283-291.
10. Afsar SK et al, Pharmacological evaluation of anti-pyretic activity of ethanolic fruit extract of Terminalia chebula in Wistar rats. IJAPR 2012;3(1):692-695.
11. Kumar CU, Pokuri VK, Pingali U, Evaluation of the analgesic activity of standardized aqueous extract of Terminalia chebula in healthy human participants using hot air pain model. J Clin Diagn Res. 2015; 9(5): FC01–FC04.