| Name: |
Tempol |
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| Synonyms: |
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| Trade name: |
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| Chemical name: |
4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl[1],[2]
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| Molecular Weight: |
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| Source: |
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| Structure: |
 [1],[3],[4]
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| Chemical Nature: |
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| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
Preclinical study-
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| Notes: |
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| REFERENCES |
| 1. |
Johnstone PA, DeGraff WG, Mitchell JB, Protection from radiation-induced chromosomal aberrations by the nitroxide Tempol. Cancer. 1995;75(9):2323-7.
http://dx.doi.org/10.1002/1097-0142(19950501)75:9<2323::AID-CNCR2820750922>3.0.CO;2-2 |
| 2. |
Cotrim AP et al, Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res. 2005;11(20):7564-8.
http://dx.doi.org/10.1158/1078-0432.CCR-05-0958 |
| 3. |
Ramachandran L, Nair CKK, Radioprotection by tempol: Studies on tissue
antioxidant levels, hematopoietic and
gastrointestinal systems, in mice whole body
exposed to sub-lethal doses of gamma radiation. Iran J Radiat Res 2012; 10(1): 1-10.
http://ijrr.com/browse.php?a_id=877&sid=1&slc_lang=en |
| 4. |
Samuni AM, Barenholz Y, Stable nitroxide radicals protect lipid acyl chains from radiation damage. Free Radic Biol Med. 1997;22(7):1165-74.
http://dx.doi.org/10.1016/S0891-5849(96)00509-6 |
