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"Radiosensitisers and Radioprotectors"

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Tempol

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


GENERAL FEATURES

Name: Tempol
Synonyms:
Trade name:
Chemical name: 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl[1],[2]
Molecular Weight:
Source:
Structure: [1],[3],[4]
Chemical Nature:
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Johnstone PA, DeGraff WG, Mitchell JB, Protection from radiation-induced chromosomal aberrations by the nitroxide Tempol. Cancer. 1995;75(9):2323-7.
http://dx.doi.org/10.1002/1097-0142(19950501)75:9<2323::AID-CNCR2820750922>3.0.CO;2-2
2. Cotrim AP et al, Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res. 2005;11(20):7564-8.
http://dx.doi.org/10.1158/1078-0432.CCR-05-0958
3. Ramachandran L, Nair CKK, Radioprotection by tempol: Studies on tissue antioxidant levels, hematopoietic and gastrointestinal systems, in mice whole body exposed to sub-lethal doses of gamma radiation. Iran J Radiat Res 2012; 10(1): 1-10.
http://ijrr.com/browse.php?a_id=877&sid=1&slc_lang=en
4. Samuni AM, Barenholz Y, Stable nitroxide radicals protect lipid acyl chains from radiation damage. Free Radic Biol Med. 1997;22(7):1165-74.
http://dx.doi.org/10.1016/S0891-5849(96)00509-6