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Sulfasalazine

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GENERAL FEATURES

Name: Sulfasalazine
Synonyms: salazosulfapyridin[1]
Accucol,
Asulfidine,
Azopyrin[2]
Trade name:
Chemical name:
Molecular Weight: 398.39 g/mol[7]
Source:
Structure: [6],[3],[7]
Chemical Nature: Sulfasalazine is a sulfa drug (a derivative of mesalazine) and is formed by combining sulfapyridine and salicylate with an azo bond.[5]
It is practically insoluble in water and ether R, slightly soluble in ehanol and soluble in alkali hydroxides.[6]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
High rate of remission in ulcerative colitis was achieved by sulfasalazine and its metabolite 5-aminosalicylic acid in patients with ulcerative colitis and Crohn's disease.[4]
Preclinical study-
Notes:
REFERENCES
1. Sulfasalazine ; In :Drug Dosage in Renal Insufficiency, Seyffart G, Springer Science & Business Media, 2012, page no. 552.
https://books.google.co.in/books?id=OavnCAAAQBAJ&pg=PA552
2. Sulfasalazine ; In: The Complete Technology Book on Fine Chemicals by NIIR Board of Consultants and Engineers, Asia Pacific Business Press Inc., 2004, page no. 173.
https://books.google.co.in/books?id=xBKmAwAAQBAJ&pg=PA173
3. 6. Oral Mesalamine by Sakuraba A; In : Medical Therapy of Ulcerative Colitis edited by Lichtenstein GR, Springer, 2014, page no. 57.
https://books.google.co.in/books?id=FDugBQAAQBAJ&pg=PA57
4. Klotz U et al, Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease. N Engl J Med. 1980 Íž303(26):1499-502.
http://dx.doi.org/10.1056/NEJM198012253032602
5. Pharmacology for Nursing Care, 6th edition, by Lehne RA, CTI Reviews, Cram101 Textbook Reviews, 2016
https://books.google.co.in/books?id=tgjRnfuHc6AC&pg=PT284
6. Monographs for Pharmaceutical Substances; In : The International Pharmacopoeia, 4th edition, Volume 2 by World Health Organization, Geneva, 2006, page no. 887.
https://books.google.co.in/books?id=s_sBKJNf184C&pg=PA887
7. Sulfasalazine by McDonnell JM ; In : Profiles of Drug Substances, Excipients and Related Methodology, volume 5, edited by Florey K, Academic Press, 1976, page no. 517.
https://books.google.co.in/books?id=v0iIT2XfrXwC&pg=PA517