| Name: |
Sucralfate |
|---|
| Synonyms: |
Aluminum sucrose sulfate[1]
|
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| Trade name: |
Sucramal in Italy,
Carafate in USA,Pepsigard, Sucral, Sucrafil, Hapifate in India,
Sulcrate in Canada[2]
Skincol® gel[3]
|
|---|
| Chemical name: |
Hexadeca-µ-hydroxytetracosahydroxy[µ8-[1,3,4,6-tetra-O-sulfo-β-D-glucopyranosidetetrakis(hydrogensulfato)(8-)]]hexadecaaluminum[4]
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| Molecular Weight: |
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| Source: |
Sucralfate is a basic aluminium salt of sucrose
octasulphate.[5]
|
| Structure: |
 [6]
|
| Chemical Nature: |
an aluminium hydroxide complex of sulphated sucrose[7]
It is practically insoluble in alcohol or water.[1]
soluble in acids and alkalis[6]
|
| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
It is indicated for treatment of active duodenal ulcers.[2]
It is used in treatment of gastroesophageal reflux disease and stress ulcers.[2]
Preclinical study-
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| Notes: |
|
| REFERENCES |
| 1. |
Sucralfate ; In : Essential Drug Data for Rational Therapy in Veterinary Practice by Eghianruwa K, Author House, 2014, page no. 373.
https://books.google.co.in/books?id=h4zCAgAAQBAJ&pg=PA373 |
| 2. |
Pharmacology, A Nursing Process Approach: Pharmaceutical sciences, CTI Reviews, Cram101 Textbook Reviews, 2016.
https://books.google.co.in/books?id=kztY0Z6_NAQC&pg=PT290 |
| 3. |
Kouloulias V et al, Sucralfate gel as a radioprotector against radiation induced dermatitis in a hypo-fractionated schedule: a non-randomized study. Hippokratia. 2013 ; 17(2): 126–129.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743615/ |
| 4. |
Sucralfate ; In : Pharmaceutical Manufacturing Encyclopedia, 3rd Edition, William Andrew Publishing, Elsevier, 2013, page no. 3078.
https://books.google.co.in/books?id=_J2ti4EkYpkC&pg=PA3078 |
| 5. |
Stockdale AD, Biswas A, Long-term control of radiation proctitis
following treatment with sucralfate enema. British Journal of Surgery 1997; 84(3): 379.
http://dx.doi.org/10.1046/j.1365-2168.1997.02587.x |
| 6. |
14. Gastrointestinal Tract Drugs; In : Part III. Pharmacodynamic Agents ; In : Essentials OF Medicinal Chemistry, 2nd Edition, by Korolkovas A, John Wiley & Sons, 2008, page no. 552.
https://books.google.co.in/books?id=8Pnr12YweocC&pg=PA552 |
| 7. |
Franzén L et al, Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study. Acta Oncol. 1995;34(2):219-23.
http://dx.doi.org/10.3109/02841869509093959 |
