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Name: Sucralfate
Synonyms: Aluminum sucrose sulfate[1]
Trade name: Sucramal in Italy,
Carafate in USA,
Pepsigard, Sucral, Sucrafil, Hapifate in India,
Sulcrate in Canada[2]
Skincol® gel[3]
Chemical name: Hexadeca-µ-hydroxytetracosahydroxy[µ8-[1,3,4,6-tetra-O-sulfo-β-D-glucopyranosidetetrakis(hydrogensulfato)(8-)]]hexadecaaluminum[4]
Molecular Weight:
Source: Sucralfate is a basic aluminium salt of sucrose octasulphate.[5]
Structure: [6]
Chemical Nature: an aluminium hydroxide complex of sulphated sucrose[7]
It is practically insoluble in alcohol or water.[1]
soluble in acids and alkalis[6]
& Indications:
Pharmcological Action-
Therapeutic indications:
It is indicated for treatment of active duodenal ulcers.[2]
It is used in treatment of gastroesophageal reflux disease and stress ulcers.[2]
Preclinical study-
1. Sucralfate ; In : Essential Drug Data for Rational Therapy in Veterinary Practice by Eghianruwa K, Author House, 2014, page no. 373.
2. Pharmacology, A Nursing Process Approach: Pharmaceutical sciences, CTI Reviews, Cram101 Textbook Reviews, 2016.
3. Kouloulias V et al, Sucralfate gel as a radioprotector against radiation induced dermatitis in a hypo-fractionated schedule: a non-randomized study. Hippokratia. 2013 ; 17(2): 126–129.
4. Sucralfate ; In : Pharmaceutical Manufacturing Encyclopedia, 3rd Edition, William Andrew Publishing, Elsevier, 2013, page no. 3078.
5. Stockdale AD, Biswas A, Long-term control of radiation proctitis following treatment with sucralfate enema. British Journal of Surgery 1997; 84(3): 379.
6. 14. Gastrointestinal Tract Drugs; In : Part III. Pharmacodynamic Agents ; In : Essentials OF Medicinal Chemistry, 2nd Edition, by Korolkovas A, John Wiley & Sons, 2008, page no. 552.
7. Franzén L et al, Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study. Acta Oncol. 1995;34(2):219-23.