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Sucralfate

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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GENERAL FEATURES

Name: Sucralfate
Synonyms: Aluminum sucrose sulfate[1]
Trade name: Sucramal in Italy,
Carafate in USA,
Pepsigard, Sucral, Sucrafil, Hapifate in India,
Sulcrate in Canada[2]
Skincol® gel[3]
Chemical name: Hexadeca-µ-hydroxytetracosahydroxy[µ8-[1,3,4,6-tetra-O-sulfo-β-D-glucopyranosidetetrakis(hydrogensulfato)(8-)]]hexadecaaluminum[4]
Molecular Weight:
Source: Sucralfate is a basic aluminium salt of sucrose octasulphate.[5]
Structure: [6]
Chemical Nature: an aluminium hydroxide complex of sulphated sucrose[7]
It is practically insoluble in alcohol or water.[1]
soluble in acids and alkalis[6]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
It is indicated for treatment of active duodenal ulcers.[2]
It is used in treatment of gastroesophageal reflux disease and stress ulcers.[2]
Preclinical study-
Notes:
REFERENCES
1. Sucralfate ; In : Essential Drug Data for Rational Therapy in Veterinary Practice by Eghianruwa K, Author House, 2014, page no. 373.
https://books.google.co.in/books?id=h4zCAgAAQBAJ&pg=PA373
2. Pharmacology, A Nursing Process Approach: Pharmaceutical sciences, CTI Reviews, Cram101 Textbook Reviews, 2016.
https://books.google.co.in/books?id=kztY0Z6_NAQC&pg=PT290
3. Kouloulias V et al, Sucralfate gel as a radioprotector against radiation induced dermatitis in a hypo-fractionated schedule: a non-randomized study. Hippokratia. 2013 ; 17(2): 126–129.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743615/
4. Sucralfate ; In : Pharmaceutical Manufacturing Encyclopedia, 3rd Edition, William Andrew Publishing, Elsevier, 2013, page no. 3078.
https://books.google.co.in/books?id=_J2ti4EkYpkC&pg=PA3078
5. Stockdale AD, Biswas A, Long-term control of radiation proctitis following treatment with sucralfate enema. British Journal of Surgery 1997; 84(3): 379.
http://dx.doi.org/10.1046/j.1365-2168.1997.02587.x
6. 14. Gastrointestinal Tract Drugs; In : Part III. Pharmacodynamic Agents ; In : Essentials OF Medicinal Chemistry, 2nd Edition, by Korolkovas A, John Wiley & Sons, 2008, page no. 552.
https://books.google.co.in/books?id=8Pnr12YweocC&pg=PA552
7. Franzén L et al, Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study. Acta Oncol. 1995;34(2):219-23.
http://dx.doi.org/10.3109/02841869509093959