Welcome to University of Mumbai, Department of Biophysics

Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

Alphabetical Search   >  S   >  Silymarin                                                                                                                                                                 Top


Go To:

General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


Name: Silymarin
Trade names: Flavobion[1]
Flavobion ("Spofa") is formed by a complex of flavonoids (silybin, silydianim, and silychristin), under the general name of silymarin[2]
Leviaderm® (silymarin-based cream)[3]
Source: Silymarin is a mixture of flavonolignans from the seeds of Silybum marianum (L.) Gaertn (commonly known as Milk thistle)[4], containing silybinin, isosilybinin, silydianin, silychristin and the dihydroflavonol of taxifolin.[5]
Seeds of Silybum marianum (L.) Gaertn:
Flavanoids, phenols, terpenoids, tannins, taxifolin, Isosilybin, Silybin, Silychristin, Silydianin[6]
& Indications:
Pharmcological Action-
hepatoprotective in rats[7], in mice[8]
chain-breaking antioxidant[8]
Therapeutic indications:
Preclinical study-
1. Haková H, Misúrová E, Kropácová K, The effect of silymarin on concentration and total content of nucleic acids in tissues of continuously irradiated rats. Vet Med (Praha). 1996 ;41(4):113-9.
2. Gakova N, Mishurova E, Kropachova K, Effect of flavobion on tissue nucleic acids of rats irradiated with gamma rays. Biull Eksp Biol Med. 1992 ;113(3):375-9.
3. Becker-Schiebe M et al, Topical use of a Silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. Strahlenther Onkol. 2011 ;187(8):485-91.
4. Milk Thistle (Silybum marianum) by Ladas E, Kroll DJ, Kelly KM ; In : Encyclopedia of Dietary Supplements, edited by Coates PM et al, CRC Press, 2004, Page no. 467.
5. Radjabian T, Rezazadeh SH, Huseini HF, Analysis of silymarin components in the seed extracts of some milk thistle ecotypes from Iran by HPLC. Iranian Journal of Science & Technology, Transaction A 2008;Article 7,32(2):141-146.
6. Atraqchi NH, Wafaa MA, Hamed AS, Preliminary phytochemical screening an in-vitro evaluation of antioxidant activity of Iraqi species of Silybum maranum seeds. Int. Res. J. Pharm. 2014; 5 (5): 378-383.
7. Muriel P et al, Silymarin protects against paracetamolinduced lipid peroxidation and liver damage. J Appl Toxicol. 1992 ;12(6):439-42.
8. Lettéron P et al, Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol. 1990 ;39(12):2027-34.