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"Radiosensitisers and Radioprotectors"

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Name: Sesamol
Trade name:
Chemical name: 5-hydroxy-1,3-benzodioxole
3,4- methylenedioxyphenol.[1],[2],[3]
Molecular Weight: 138.12 g/mol[10]
Source: It is the constituent of sesame (Sesamum indicum) seeds.[4], and seed oil[3]
Structure: [5],[2],[6],[7]
Chemical Nature: Sesamol is indicated to possess hydrogen/ electron donation capacity.[6]
Sesamol is soluble in aqueous as well as lipid phases[8]
& Indications:
Pharmcological Action-
hepatoprotective in rats[9]
Therapeutic indications:
Preclinical study-
1. Parihar VK et al, Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2006;611(1–2):9–16.
2. Nair GG, Nair CKK, Amelioration of gamma-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol. Int. J. Low Radiation 2011;8(1):20-34.
3. Chapter 8. Nonnutrient Antioxidants and Stability of Fryin Oils by Boskou D ; In : Frying of Food: Oxidation, Nutrient and Non-Nutrient Antioxidants, Biologically Active Compounds and High Temperatures, Second Edition by Boskou D, Elmadfa I, CRC Press, 2016, page no. 209.
4. Kuo PC et al, Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans. J. Agric. Food Chem. 2011; 59 (7):3214–3219.
5. Nair GG, Nair CKK, Protection of Cellular DNA and Membrane from gamma-Radiation–Induced Damages and Enhancement in DNA Repair by Sesamol. Cancer Biotherapy and Radiopharmaceuticals. 2011; 25(6): 629-635.
6. Sesamol as a potential radioprotective agent: in vitro studies. Radiat Res 2011; 176(5):613-623.
7. Chapter 2. Composition, Structure, Physical Data and Chemical Reactions of Fat and Oils and Their Associates; In : Fats and Oils Handbook, by Bockisch M, Elsevier, 2015, page no. 113.
8. Joshi R et al, Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies. J Agric Food Chem. 2005;53(7):2696-703.
9. Ohta S et al, Protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats. Yakugaku Zasshi. 1994;114(11):901-10.
10. Majdalawieh AF, Ro HS, Sesamol and sesame (Sesamum indicum) oil enhance macrophage cholesterol efflux via up-regulation of PPARγ1 and LXRα transcriptional activity in a MAPK-dependent manner. Eur J Nutr 2015;54(5):691–700.