| Name: |
Sesamol |
|---|
| Trade name: |
|
|---|
| Chemical name: |
5-hydroxy-1,3-benzodioxole 3,4-
methylenedioxyphenol.[1],[2],[3]
|
|---|
| Molecular Weight: |
138.12 g/mol[10]
|
|---|
| Source: |
It is the constituent of sesame (Sesamum indicum) seeds.[4], and seed oil[3]
|
| Structure: |
 [5],[2],[6],[7]
|
| Chemical Nature: |
Sesamol is indicated to possess hydrogen/
electron donation capacity.[6]
Sesamol is soluble in aqueous as well as lipid
phases[8]
|
| Actions & Indications: |
Pharmcological Action-
hepatoprotective in rats[9]
Therapeutic indications:
Preclinical study-
|
| Notes: |
|
| REFERENCES |
| 1. |
Parihar VK et al, Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2006;611(1–2):9–16.
http://dx.doi.org/10.1016/j.mrgentox.2006.06.037 |
| 2. |
Nair GG, Nair CKK, Amelioration of gamma-radiation induced genomic insult
and oxidative stress in whole body irradiated Swiss
albino mice by sesamol. Int. J. Low Radiation 2011;8(1):20-34.
http://dx.doi.org/10.1504/IJLR.2011.040646 |
| 3. |
Chapter 8. Nonnutrient Antioxidants and Stability of Fryin Oils by Boskou D ; In : Frying of Food: Oxidation, Nutrient and Non-Nutrient Antioxidants, Biologically Active Compounds and High Temperatures, Second Edition by Boskou D, Elmadfa I, CRC Press, 2016, page no. 209.
https://books.google.co.in/books?id=3AvMBQAAQBAJ&pg=PA209 |
| 4. |
Kuo PC et al, Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans. J. Agric. Food Chem. 2011; 59 (7):3214–3219.
http://dx.doi.org/10.1021/jf104311g |
| 5. |
Nair GG, Nair CKK, Protection of Cellular DNA and Membrane from gamma-Radiation–Induced Damages and Enhancement in DNA Repair by Sesamol. Cancer Biotherapy and Radiopharmaceuticals. 2011; 25(6): 629-635.
http://dx.doi.org/10.1089/cbr.2010.0803 |
| 6. |
Sesamol as a potential radioprotective agent: in vitro studies. Radiat Res 2011; 176(5):613-623.
http://dx.doi.org/10.1667/RR2661.1 |
| 7. |
Chapter 2. Composition, Structure, Physical Data and Chemical Reactions of Fat and Oils and Their Associates; In : Fats and Oils Handbook, by Bockisch M, Elsevier, 2015, page no. 113.
https://books.google.co.in/books?id=psxcCgAAQBAJ&pg=PA113 |
| 8. |
Joshi R et al, Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies. J Agric Food Chem. 2005;53(7):2696-703.
http://dx.doi.org/10.1021/jf0489769 |
| 9. |
Ohta S et al, Protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats. Yakugaku Zasshi. 1994;114(11):901-10.
https://www.ncbi.nlm.nih.gov/pubmed/7853152 |
| 10. |
Majdalawieh AF, Ro HS, Sesamol and sesame (Sesamum indicum) oil enhance macrophage
cholesterol efflux via up-regulation of PPARγ1 and LXRα
transcriptional activity in a MAPK-dependent manner. Eur J Nutr 2015;54(5):691–700.
http://dx.doi.org/10.1007/s00394-014-0747-3 |
