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Rutin

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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GENERAL FEATURES

Name: Rutin
Synonyms: Rutoside[1]
Trade name:
Chemical name: quercetin-3-O-rutinoside[2]
2-[[6-O-(6-Deoxy-αa-L-mannopyranosyl)-βb-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one[1]
IUPAC name:
3-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl-oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one[3]
Molecular Weight: 610.52 g/mol[1],[3]
Source: Rutin is widely distributed throughout the higher plants, mainly from fruits, vegetables and plant-derived beverages. Also could be obtained mainly from Fagopyrum vulgare , Eucalyptus macrohyncha, and Sophora japonica[1]
Structure: [1],[4]
Chemical Nature: a flavonol glycoside[5]
slightly soluble in water, soluble in ethanol[3]
Actions
& Indications:
Pharmcological Action-
hepatoprotective in rodents[6]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. 35. Rutin ; In : Active Ingredients Used in Cosmetics: Safety Survey edited by Council of Europe. Committee of Experts on Cosmetic Products, Council of Europe, 2008, page no. 343.
https://books.google.co.in/books?id=tWJLUWT06BEC&pg=PA343
2. Laires A, Pacheco P, Rueff J, Mutagenicity of rutin and the glycosidic activity of cultured cell-free microbial preparations of human faeces and saliva. Food Chem Toxicol. 1989;27(7):437-43.
http://dx.doi.org/10.1016/0278-6915(89)90029-X
3. 21. Rutin ; In : Plantes Dans Les Cosmétiques, Council of Europe, 2006, page no. 221.
https://books.google.co.in/books?id=ado5bA4lyo8C&pg=PA221
4. Křížková J et al, The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine. Interdisc Toxicol. 2009; 2(3): 201–204.
http://dx.doi.org/10.2478/v10102-009-0018-y
5. Wilson RH, Mortarotti TG, Doxtader EK, Toxicity studies on rutin. Proc Soc Exp Biol Med. 1947 ;64(3):324-7.
http://dx.doi.org/10.3181/00379727-64-15781
6. Janbaz KH, Saeed SA, Gilani AH, Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia. 2002;73(78):557-63.
http://dx.doi.org/10.1016/S0367-326X(02)00217-4