Welcome to University of Mumbai, Department of Biophysics

Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

Alphabetical Search   >  R   >  Rubia cordifolia                                                                                                                                                                 Top

Rubia cordifolia

Go To:

General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


Name: Rubia cordifolia
Synonyms/Scientific names: Rubia cordifolia Linn.[1]
Synonyms/common names :
Indian madder, munjeet[2],[1]
Trade name:
Description: Family : Rubiaceae[2],[1]
Extract used: hydroalcoholic root extract[3], alcoholic root extract[4] and aqueous root extract [5] has been used for radioprotection study.
Rubiadin, a dihydroxy anthraquinone[6]
Roots :
Rubiacordone A[7]
mollugin, 1-hydroxy-2-methyl-9, 10-anthraquinone, alizarin, 1, 3-dihydroxy-2-ethoxymethyl-9, 10-anthraquinone, lucidin primeveroside, ruberythric acid and three new anthraquinones, 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone, 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone 3-O-(6'-O-acetyl)-α-rhamnosyl-(1→2)-β-glucoside and 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone 3-O-α-rhamnosyl (1→2)-β-glucoside[8]
furomollugin, mollugin and dehydro- α-lapchone[9]
alizarin, rubimaillin[10]
& Indications:
Pharmcological Action-
anti-inflammatoty in animals[3]
hypoglycemic in diabetic rats[11]
diuretic in rats[12]
Therapeutic indications:
traditionally used for vaginal diseases, eye diseases, bronchial inflammation, ear diseases, menorrhagia, diarrhea with blood, urinary disorders, snake bite, piles.[1]
Preclinical study-
1. Ayurvedic Pharmacopoeial Plant Drugs: Expanded Therapeutics by Khare CP, CRC Press, 2015, Page no. 483.
2. Dyes and Tannins, by Jansen PCM, Cardon D, PROTA, 2005, Page no. 141.
3. Chapter 5 : Radioprotective, nephoprotective and anti-inflammatory activities of the plant Rubia cordifolia Linn. ; In : Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance, a thesis by Joy J, Guide : Nair CKK, submitted to Mahatma Gandhi University, Amala Cancer Research Center, India, 2014.
4. Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology 2007; 45(7):620-625.
5. Kamat JP, Mishra, KP, Radioprotection by Rubia cordifolia: studies on mitochondrial membranes. Sixteenth annual conference of Indian Nuclear Society: science behind nuclear technology. Mumbai (India); 15-18 Nov 2005.
6. Tripathi YB, Sharma M, Manickam M, Rubiadin, a new antioxidant from Rubia cordifolia. Indian J Biochem Biophys. 1997;34(3):302-6.
7. Li X et al, Rubiacordone A: A New anthraquinone glycoside from the roots of Rubia cordifolia. Molecules 2009; 14: 566-572.
8. Itokawa H, Mihara K, Takeya K, Studies on a novel anthraquinone and its glycosides isolated from Rubia cordifolia and R. akane. Chem. Pharm. Bull. 1983;31(7):2353-2358.
9. Gupta PP et al, Biological activity of Rubia cordifolia and isolation of an active principle. Pharmaceutical Biology 1999; 37(1): 46–49.
10. Yang HS et al, Simultaneous determination of alizarin and rubimaillin in Rubia cordifolia by ultrasound-assisted ionic liquid-reversed phase liquid chromatography. Zhongguo Zhong Yao Za Zhi. 2015;40(13):2617-23.
11. Somani RS, Jain KS, Singhai AK, Hypoglycemic activity of roots of Rubia cordifolia in normal and diabetic rats. Pharmacologyonline 2007;1: 162-169.
12. Pawar AT et al, Diuretic activity of root extract of Rubia cordifolia Linn. Pharmacologyonline 2009;1: 597-603.