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Rubia cordifolia

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GENERAL FEATURES

Name: Rubia cordifolia
Synonyms/Scientific names: Rubia cordifolia Linn.[1]
Synonyms/common names :
Indian madder, munjeet[2],[1]
Manjishtha[1]
Trade name:
Description: Family : Rubiaceae[2],[1]
Extract used: hydroalcoholic root extract[3], alcoholic root extract[4] and aqueous root extract [5] has been used for radioprotection study.
Phyto-constituents
(active):
Rubiadin, a dihydroxy anthraquinone[6]
Roots :
Rubiacordone A[7]
mollugin, 1-hydroxy-2-methyl-9, 10-anthraquinone, alizarin, 1, 3-dihydroxy-2-ethoxymethyl-9, 10-anthraquinone, lucidin primeveroside, ruberythric acid and three new anthraquinones, 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone, 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone 3-O-(6'-O-acetyl)-α-rhamnosyl-(1→2)-β-glucoside and 2-methyl-1, 3, 6-trihydroxy-9, 10-anthraquinone 3-O-α-rhamnosyl (1→2)-β-glucoside[8]
furomollugin, mollugin and dehydro- α-lapchone[9]
alizarin, rubimaillin[10]
Actions
& Indications:
Pharmcological Action-
anti-inflammatoty in animals[3]
hypoglycemic in diabetic rats[11]
diuretic in rats[12]
Therapeutic indications:
traditionally used for vaginal diseases, eye diseases, bronchial inflammation, ear diseases, menorrhagia, diarrhea with blood, urinary disorders, snake bite, piles.[1]
Preclinical study-
Notes:
REFERENCES
1. Ayurvedic Pharmacopoeial Plant Drugs: Expanded Therapeutics by Khare CP, CRC Press, 2015, Page no. 483.
https://books.google.com/books?id=MSbSCgAAQBAJ&pg=PA483
2. Dyes and Tannins, by Jansen PCM, Cardon D, PROTA, 2005, Page no. 141.
https://books.google.com/books?id=dVBYe0SK1TwC&pg=PA141
3. Chapter 5 : Radioprotective, nephoprotective and anti-inflammatory activities of the plant Rubia cordifolia Linn. ; In : Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance, a thesis by Joy J, Guide : Nair CKK, submitted to Mahatma Gandhi University, Amala Cancer Research Center, India, 2014.
http://shodhganga.inflibnet.ac.in/handle/10603/25801
4. Tripathi YB, Singh AV, Role of Rubia cordifolia Linn. in radiation protection. Indian Journal of Experimental Biology 2007; 45(7):620-625.
http://nopr.niscair.res.in/bitstream/123456789/5335/1/IJEB%2045(7)%20620-625.pdf
5. Kamat JP, Mishra, KP, Radioprotection by Rubia cordifolia: studies on mitochondrial membranes. Sixteenth annual conference of Indian Nuclear Society: science behind nuclear technology. Mumbai (India); 15-18 Nov 2005.
https://inis.iaea.org/search/search.aspx?orig_q=RN:37061834
6. Tripathi YB, Sharma M, Manickam M, Rubiadin, a new antioxidant from Rubia cordifolia. Indian J Biochem Biophys. 1997;34(3):302-6.
http://www.ncbi.nlm.nih.gov/pubmed/9425750
7. Li X et al, Rubiacordone A: A New anthraquinone glycoside from the roots of Rubia cordifolia. Molecules 2009; 14: 566-572.
http://dx.doi.org/10.3390/molecules14010566
8. Itokawa H, Mihara K, Takeya K, Studies on a novel anthraquinone and its glycosides isolated from Rubia cordifolia and R. akane. Chem. Pharm. Bull. 1983;31(7):2353-2358.
http://doi.org/10.1248/cpb.31.2353
9. Gupta PP et al, Biological activity of Rubia cordifolia and isolation of an active principle. Pharmaceutical Biology 1999; 37(1): 46–49.
http://dx.doi.org/10.1076/phbi.37.1.46.6322
10. Yang HS et al, Simultaneous determination of alizarin and rubimaillin in Rubia cordifolia by ultrasound-assisted ionic liquid-reversed phase liquid chromatography. Zhongguo Zhong Yao Za Zhi. 2015;40(13):2617-23.
http://www.ncbi.nlm.nih.gov/pubmed/26697688
11. Somani RS, Jain KS, Singhai AK, Hypoglycemic activity of roots of Rubia cordifolia in normal and diabetic rats. Pharmacologyonline 2007;1: 162-169.
http://pharmacologyonline.silae.it/files/archives/2007/vol1/20_SomaniOK.pdf
12. Pawar AT et al, Diuretic activity of root extract of Rubia cordifolia Linn. Pharmacologyonline 2009;1: 597-603.
http://pharmacologyonline.silae.it/files/archives/2009/vol1/063.Pawar.pdf