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Resveratrol

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GENERAL FEATURES

Name: Resveratrol
Synonyms:
Trade name: resVida®[1]
Chemical name: Resveratrol (3, 4', 5- trihydroxystilbene)[2],[3]
Molecular Weight: 228.25 g/mol[4]
Source: It is found in grapes, peanuts, peanut butter, pines, wine, and also in a weed Polygonum cuspidatum[5],[6],[13]
Structure:
trans-resveratrol[7],[8], [9]
Chemical Nature: a natural diphenol[13]
It is a stilbenoid, a derivative of stilbene.[3]
lipophilic in nature[10]
Actions
& Indications:
Pharmcological Action-
Found to be antimetastatic in experimental cancer model[13]
anti-inflammatory(trans-resveratrol)[11]
Therapeutic indications:
Preclinical study-
Resveratrol sensitivity: U251 cell were found to be sensitive to resveratrol while LN229 cells were found to be insensitive.[12
REFERENCES
1. Edwards JA et al, Safety of resveratrol with examples for high purity, trans-resveratrol, resVida(®). Ann N Y Acad Sci. 2011;1215:131-7.
http://dx.doi.org/10.1111/j.1749-6632.2010.05855.x
2. Win W et al, Different effects of genistein and resveratrol on oxidative DNA damage in vitro. Mutat Res 2002;513(1-2):113–120.
http://dx.doi.org/10.1016/S1383-5718(01)00303-5
3. Venugopal R, Liu RH, Phytochemicals in diets for breast cancer prevention: The importance of resveratrol and ursolic acid. Food Science and Human Wellness 2012;1(1):1–13.
http://dx.doi.org/10.1016/j.fshw.2012.12.001
4. Chapter 2. Sources and Chemsitry of Resveratrol by Seeram NP, Kulkarni VV, Padhye S; In :Resveratrol in Health and Disease edited by Aggarwal BB, Shishodia S, CRC Press, 2005, page no. 23.
https://books.google.co.in/books?id=g-HLBQAAQBAJ&pg=PA23
5. Chapter 10. Alcohol, coffee and sugars Evidence benefits and advice ; In : Lifestyle After Cancer: The Facts by Thomas RJ, Health Education publications, 2008, page no. 99.
https://books.google.co.in/books?id=1Y3RbwjvvtkC&pg=PA99
6. Chapter 6. The French paradox and the holy grail of aging; In : The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life by Maroon J, Simon and Schuster, 2008.
https://books.google.co.in/books?id=VgeF0jK3olQC&pg=PT71
7. Dobrydneva Y, Williams RL, Blackmore PF, trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br J Pharmacol. 1999;128(1):149-57.
http://dx.doi.org/10.1038/sj.bjp.0702749
8. Camont L et al, Radical-induced oxidation of trans-resveratrol. Biochimie 2012;94:741-747.
http://dx.doi.org/10.1016/j.biochi.2011.11.005
9. Rhayem Y et al, Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. Chem Phys Lipids. 2008;155(1):48-56.
http://dx.doi.org/10.1016/j.chemphyslip.2008.06.001
10. Belguendouz L, Frémont L, Gozzelino MT, Interaction of trans-resveratrol with plasma lipoproteins. Biochem Pharmacol 1998;55(6):811-6.
http://dx.doi.org/10.1016/S0006-2952(97)00544-3
11. Tan Y, Lim LHK, trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. Br J Pharmacol. 2008; 155(7): 995–1004.
http://dx.doi.org/10.1038/bjp.2008.330
12. Sun Z et al, Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells. FEBS J. 2012;279(13):2381-92.
http://dx.doi.org/10.1111/j.1742-4658.2012.08617.x
13. Busquets S et al, Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. Cancer Lett. 2007;245(1-2):144-8.
http://dx.doi.org/10.1016/j.canlet.2005.12.035