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Podophyllum hexandrum

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GENERAL FEATURES

Name: Podophyllum hexandrum
Synonyms/
Scientific names:
Podophyllum hexandrum Royle.[1],[2]
Synonyms/common names :
Himalayan mayapple[2]
Podophyllum emodi[2]
Indian Podophyllum[1]
Trade name:
Description: Family : Berberidaceae[1]
Extract used:
Phyto-constituents
(active):
podophyllotoxin, picropodophytlin[3]
Phthalic acid, diisobutyl ester, 1,2-Benzenedicarboxylic acid, diisooctyl ester, Polyneuridine, β-Sitosterol and Podophyllotoxin, campesterol[4]
Actions
& Indications:
Pharmcological Action-
immunostimulatory in mice.[5]
anti-inflammatory in mice.[6]
hepatoprotective in rat.[7],[8]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Podophyllum hexandrum Royle. ; In : Indian Medicinal Plants: An Illustrated Dictionary by Khare CP, Springer Science & Business Media, 2008, page no. 503.
https://books.google.co.in/books?id=gMwLwbUwtfkC&pg=PA503
2. 9. Himalayan Mayapple:Traditional uses, clinical indications and future prospects by Arora R et al; In : Botanical Medicine in Clinical Practice by Watson RR, Preedy VR, CABI, 2008, page no. 73.
https://books.google.co.in/books?id=j5PdVtMgVLYC&pg=PA73
3. Chakravarti SS, Chakraborty DP, Chemical examination of Podophyllum emodi wall. Var. hexandrum (royle). J Am Pharm Assoc Am Pharm Assoc. 1954;43(10):614-5.
http://dx.doi.org/10.1002/jps.3030431012
4. Li M et al, Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complementary and Altern Med 2012;12:263.
http://dx.doi.org/10.1186/1472-6882-12-263
5. Goel HC et al, Podophyllum hexandrum modulates gamma radiation-induced immunosuppression in Balb/c mice: Implications in radioprotection. Molecular and Cellular Biochemistry 2007;295: 93–103.
http://dx.doi.org/10.1007/s11010-006-9277-5
6. Prakash H et al, Anti-inflammatory effects of Podophyllum hexandrum (RP-1) against lipopolysaccharides induced inflammation in mice. J Pharm Pharmaceut Sci 2005;8(1):107-114.
7. Ganie SA et al, Antioxidant and protective effect of ethyl acetate extract of Podophyllum hexandrum rhizome on Carbon tetrachloride induced rat liver injury. Evidence-Based Complementary and Alternative Medicine Volume 2011; Article ID 238020, 12 pages.
http://dx.doi.org/10.1155/2011/238020
8. Ganie SA et al, Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum. BMC Complement Altern Med 2011; 11:17.
http://dx.doi.org/10.1186/1472-6882-11-17