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Podophyllum hexandrum

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Name: Podophyllum hexandrum
Scientific names:
Podophyllum hexandrum Royle.[1],[2]
Synonyms/common names :
Himalayan mayapple[2]
Podophyllum emodi[2]
Indian Podophyllum[1]
Trade name:
Description: Family : Berberidaceae[1]
Extract used:
podophyllotoxin, picropodophytlin[3]
Phthalic acid, diisobutyl ester, 1,2-Benzenedicarboxylic acid, diisooctyl ester, Polyneuridine, β-Sitosterol and Podophyllotoxin, campesterol[4]
& Indications:
Pharmcological Action-
immunostimulatory in mice.[5]
anti-inflammatory in mice.[6]
hepatoprotective in rat.[7],[8]
Therapeutic indications:
Preclinical study-
1. Podophyllum hexandrum Royle. ; In : Indian Medicinal Plants: An Illustrated Dictionary by Khare CP, Springer Science & Business Media, 2008, page no. 503.
2. 9. Himalayan Mayapple:Traditional uses, clinical indications and future prospects by Arora R et al; In : Botanical Medicine in Clinical Practice by Watson RR, Preedy VR, CABI, 2008, page no. 73.
3. Chakravarti SS, Chakraborty DP, Chemical examination of Podophyllum emodi wall. Var. hexandrum (royle). J Am Pharm Assoc Am Pharm Assoc. 1954;43(10):614-5.
4. Li M et al, Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complementary and Altern Med 2012;12:263.
5. Goel HC et al, Podophyllum hexandrum modulates gamma radiation-induced immunosuppression in Balb/c mice: Implications in radioprotection. Molecular and Cellular Biochemistry 2007;295: 93–103.
6. Prakash H et al, Anti-inflammatory effects of Podophyllum hexandrum (RP-1) against lipopolysaccharides induced inflammation in mice. J Pharm Pharmaceut Sci 2005;8(1):107-114.
7. Ganie SA et al, Antioxidant and protective effect of ethyl acetate extract of Podophyllum hexandrum rhizome on Carbon tetrachloride induced rat liver injury. Evidence-Based Complementary and Alternative Medicine Volume 2011; Article ID 238020, 12 pages.
8. Ganie SA et al, Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum. BMC Complement Altern Med 2011; 11:17.