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Nigella sativa

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


GENERAL FEATURES

Name: Nigella sativa
Synonyms/Scientific names: Nigella sativa L.[1]
Nigella indica Roxb.
Nigella truncata Viv.[2]
Nigella cretica Mill.[1]
Synonyms/common names :
Black cumin, Black caraway, black seed[1]
Trade name:
Description: Family: Ranunculaceae[2],[1]
Extract used: seed:
methanolic seed extract has been used in radioprotection study[3]
ethanolic seed extract has been used in radioprotection study[4]
Phyto-constituents
(active):
seed:
alkaloid : nigellicine[5],Nigellidine[6]
triterpenoid saponin[7]
Sterols: Campesterol, Stigmasterol , β-Sitosterol
Myristic acid, Palmitic acid, Stearic acid, Oleic acid, Linoleic acid, Arachidic acid(trace), Eicosadienoic acid
tocopherols, vitamin B1, B2, B6, niacin, folic acid[8]
Borneol, Pinocarvone, β-Myrcene, Thymoquinone, Thymol, Carvacrol, 2-Undecanone,Cyclosativene, α-Longicyclene α-Copaene, α-Longifolene,Tricyclene, Camphene, β-Pinene, 1,8-Cineole, palmitic acid[9]
Seed oil
thymoquinone and carvacrol, t-anethole, sabinene and 4-terpineol[10]
dithymoquinone, thymohydroquinone and thymol[11]
p-cymene, α-thujene, thymohydroquinone, longifolene, linoleic acid, oleic acid, palmitic acid, sitosterol, Carvacrol, β-Eudesmol, α-Eudesmol, 1,8-Cineole, Sabinene, limonene, α-Phellandrene[12]
Cholesterol, Campesterol, Stigmasterol, β-Sitosterol, delta5-Avenasterol, delta7-Stigmasterol, delta7-Avenasterol in seed oil from Morocco[13]
Roots, stem and bark:
Actions
& Indications:
Pharmcological Action-
cardioprotective in rats[14]
anti-inflammatory, analgesic, antipyretic in animal models[15]
hypoglycemic effect in rabbits[16]
hepatoprotective in rats[17]
immunomodulatory[18]
anti-oxidant and pro-oxidant[19]
Therapeutic indications:
Preclinical study-
In a clinical trial, seed extract supplement proved to be antihypertensive in patients with mild hypertension[20]
Notes:
REFERENCES
1. Nigella sativa ; In: Edible Medicinal And Non-Medicinal Plants: Volume 5, Fruits, by Lim TK, Springer, 2013, Page no. 506
https://books.google.com.sg/books?id=_ZZEAAAAQBAJ&pg=PA506
2. Duke's Handbook of Medicinal Plants of the Bible, by Duke JA, Duke PK, Ducellier JL, CRC Press, 2008, Page no. 298
https://books.google.com.sg/books?id=UcLYLpwdcm8C&pg=PA298
3. Jagetia GC, Ravikiran PB, Radioprotective potential of Nigella Sativa extract in Swiss Albino Mice exposed to whole Body γ-radiation. Altern Integr Med 2014; 3(4):1-9.
http://dx.doi.org/10.4172/2327-5162.1000168
4. Rastogi L et l, Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L. Int. J. Radiat. Biol. 2010;86(9):719–731.
http://dx.doi.org/10.3109/09553002.2010.484480
5. Rahman A, Cun-heng SM, Clardy J, Isolation and structure determination of nigellicine, a novel alkaloid from the seeds of Nigella sativa. Tetrahedron Letters 1985;26(23):2759–2762.
http://dx.doi.org/10.1016/S00404039(00)949049
6. Rahman A et al, Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa. Tetrahedron Letters. 1995;36(12):1993–1996.
http://dx.doi.org/10.1016/00404039( 95)002104
7. Ansari AA et al, Structural studies on a saponin isolated from Nigella sativa. Phytochemistry. 1988;21(12):3971-3919.
http://dx.doi.org/10.1016/0031-9422(88)83062-0
8. Nergiz C, Ötleş S, Chemical composition of Nigella sativa L. seeds. Food Chemistry 1993;48: 259-261.
http://dx.doi.org/10.1016/0308-8146(93)90137-5
9. Venkatachallam SKT et al, Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. J Food Sci Technol. 2010;47(6):598–605.
http://dx.doi.org/10.1007/s13197-010-0109-y
10. Burits M, Bucar F, Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000;14(5):3238.
http://www.ncbi.nlm.nih.gov/pubmed/10925395
11. Ghosheh OA, Houdi AA, Crooks PA, High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis 1999;29: 757–762.
http://dx.doi.org/10.1016/S0731-7085(98)00300-8
12. Singh S et al, Composition, in vitro antioxidant and antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (Nigella sativa L.). BioMed Research International Volume 2014, Article ID 918209, 10 pages
http://dx.doi.org/10.1155/2014/918209
13. Gharby S et al, Chemical investigation of Nigella sativa L. seed oil produced in Morocco. Journal of the Saudi Society of Agricultural Sciences 2015; 14(2)172–177.
http://dx.doi.org/10.1016/j.jssas.2013.12.001
14. Ebru U et al, Cardioprotective effects of Nigella sativa oil on cyclosporine Ainduced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol. 2008;103(6):574-80.
http://dx.doi.org/10.1111/j.17427843.2008.00313.x
15. Al-Ghamdi MS, The anti-inflammatory, analgesic and anti-pyretic activity of Nigella sativa. Journal of Ethnopharmacology 2001;76(1):45–48.
http://dx.doi.org/10.1016/S0378-8741(01)00216-1
16. Al-Hader A, Aqel M, Hasan Z, Hypoglycemic effects of the volatile oil of Nigella sativa seeds. International Journal of Pharmacognosy. 1993;31(2):96-100.
http://dx.doi.org/10.3109/13880209309082925
17. Kanter M, Coskun O, Budancamanak M, Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloridetreated rats. World J Gastroenterol. 2005;11(42):6684-8.
http://www.ncbi.nlm.nih.gov/pubmed/16425366
18. Salem ML, Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5(13-14): 1749-70.
http://dx.doi.org/10.1016/j.intimp.2005.06.008
19. Wajid N et al, Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant. Adv. life sci. 2014; 1(2):79-88.
http://www.als-journal.com/manuscriptid28-80-2/
20. Dehkordi FR, Kamkhah AF, Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008;22(4):447-52.
http://dx.doi.org/10.1111/j.14728206.2008.00607. x