| Name: |
Misoprostol |
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| Synonyms: |
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| Trade name: |
Cytotec®,
Searle pharmaceuticals, Skokie, IL[1]
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| Chemical name: |
(11α, 13E)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester[2]
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| Molecular Weight: |
382.541 g/mol[2]
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| Source: |
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| Structure: |
 [2]
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| Chemical Nature: |
Misoprostol is a synthetic analogue of prostaglandin E1[3]
It is a hydrophobic compound, can participate in hydrogen bonding, both as an acceptor and donor.[2]
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| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
It is used for the prevention of NSAID-induced gastric ulcers.[2]
Preclinical study-
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| Notes: |
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| REFERENCES |
| 1. |
Khan AM et al, A prospective randomized placebo-controlled double-blinded pilot study of misoprostol rectal suppositories in the prevention of acute and chronic radiation proctitis symptoms in prostate cancer patients. Am J Gastroenterol. 2000 ;95(8):1961-6.
http://dx.doi.org/10.1111/j.1572-0241.2000.02260.x |
| 2. |
Chapter 19. Misoprostol ; In : Human Developmental Toxicants: Aspects of Toxicology and Chemistry by Schardein JL, Macina OT, CRC Press, 2006, page no. 95.
https://books.google.co.in/books?id=8_Lc58cGZj0C&pg=PA95 |
| 3. |
Garris RE, Kirkwood CF, Misoprostol: a prostaglandin E1 analogue. Clin Pharm. 1989 Íž8(9):627-44.
https://www.ncbi.nlm.nih.gov/pubmed/2507215 |
