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Misoprostol

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GENERAL FEATURES

Name: Misoprostol
Synonyms:
Trade name: Cytotec®, Searle pharmaceuticals, Skokie, IL[1]
Chemical name: (11α, 13E)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester[2]
Molecular Weight: 382.541 g/mol[2]
Source:
Structure: [2]
Chemical Nature: Misoprostol is a synthetic analogue of prostaglandin E1[3]
It is a hydrophobic compound, can participate in hydrogen bonding, both as an acceptor and donor.[2]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
It is used for the prevention of NSAID-induced gastric ulcers.[2]
Preclinical study-
Notes:
REFERENCES
1. Khan AM et al, A prospective randomized placebo-controlled double-blinded pilot study of misoprostol rectal suppositories in the prevention of acute and chronic radiation proctitis symptoms in prostate cancer patients. Am J Gastroenterol. 2000 ;95(8):1961-6.
http://dx.doi.org/10.1111/j.1572-0241.2000.02260.x
2. Chapter 19. Misoprostol ; In : Human Developmental Toxicants: Aspects of Toxicology and Chemistry by Schardein JL, Macina OT, CRC Press, 2006, page no. 95.
https://books.google.co.in/books?id=8_Lc58cGZj0C&pg=PA95
3. Garris RE, Kirkwood CF, Misoprostol: a prostaglandin E1 analogue. Clin Pharm. 1989 Íž8(9):627-44.
https://www.ncbi.nlm.nih.gov/pubmed/2507215