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Methotrexate

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GENERAL FEATURES

Name: Methotrexate
Synonyms: Amethopterin[1],[3]
emtrexate, methylaminopterin[6]
Trade name: Rheumatrex, Trexall[2], Folex[3]
Chemical name: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]benzoyl]-L-glutamic acid[4]
Molecular Weight: 454.45 g/mol[4]
Source:
Structure: [1],[3]
Chemical Nature: Methotrexate is a folic acid antagonist.[5]
It is a weak acid, only slightly soluble in water and alcohol.[4]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
It is used as first-line treatment of gestational choriocarcinoma, chorioadenoma destruens, hydatidiform mole.[4]
It is used in the prophylaxis and treatment of meningeal leukemia.[4]
Preclinical study-
Notes:
REFERENCES
1. Chapter 19: Nitrogen metabolism: nucleotide metabolism; In: Biochemistry and Molecular Biology, 5th edition, by Papachristodoulou D et al, OUP Oxford, 2014, page no. 219.
https://books.google.co.in/books?id=oPtzBAAAQBAJ&pg=PA291
2. Section III: Pharmacopeia for the rheumatic diseases; In : Rheumatology: Diagnosis and Therapeutics, edited by Cush JJ, Kavanaugh A, Stein CM, Lippincott Williams & Wilkins, 2005, page no. 482.
https://books.google.com.sg/books?id=e2eMlwknpAIC&pg=PA482
3. Methotreaxate; In :Essential Drug Data for Rational Therapy in Veterinary Practice By Eghianruwa K, Author House, 2014, page no. 271.
https://books.google.co.in/books?id=h4zCAgAAQBAJ&pg=PA271
4. Chapter 14: Pharmacology and Therapeutics in Gynecologic Cancer by Alberts DS et al ; In : Principles and Practice of Gynecologic Oncology 6th edition By Barakat R et al, Lippincott Williams & Wilkins, 2013, page no. 1319.
https://books.google.co.in/books?id=7QbZCx5d-zoC&pg=PT1319
5. Spittle MF, Methotrexate and radiation. Int J Radiat Oncol Biol Phys. 1978 ;4(1-2):103-7.
http://dx.doi.org/10.1016/0360-3016(78)90123-2
6. Methotreaxate; In : Hazardous Laboratory Chemicals Disposal Guide, Third Edition By Armour MA, CRC Press,2016, page no. 304.
https://books.google.co.in/books?id=bLV55kunjA4C&pg=PA304