| Name: |
Methotrexate |
|---|
| Synonyms: |
Amethopterin[1],[3]
emtrexate, methylaminopterin[6]
|
|---|
| Trade name: |
Rheumatrex, Trexall[2], Folex[3]
|
|---|
| Chemical name: |
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]benzoyl]-L-glutamic acid[4]
|
|---|
| Molecular Weight: |
454.45 g/mol[4]
|
|---|
| Source: |
|
| Structure: |
 [1],[3]
|
| Chemical Nature: |
Methotrexate is a folic acid antagonist.[5]
It is a weak acid, only slightly soluble in water and alcohol.[4]
|
| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
It is used as first-line treatment of gestational choriocarcinoma, chorioadenoma destruens, hydatidiform mole.[4]
It is used in the prophylaxis and treatment of meningeal leukemia.[4]
Preclinical study-
|
| Notes: |
|
| REFERENCES |
| 1. |
Chapter 19: Nitrogen metabolism: nucleotide metabolism; In: Biochemistry and Molecular Biology, 5th edition, by Papachristodoulou D et al, OUP Oxford, 2014, page no. 219.
https://books.google.co.in/books?id=oPtzBAAAQBAJ&pg=PA291 |
| 2. |
Section III: Pharmacopeia for the rheumatic diseases; In : Rheumatology: Diagnosis and Therapeutics, edited by Cush JJ, Kavanaugh A, Stein CM, Lippincott Williams & Wilkins, 2005, page no. 482.
https://books.google.com.sg/books?id=e2eMlwknpAIC&pg=PA482 |
| 3. |
Methotreaxate; In :Essential Drug Data for Rational Therapy in Veterinary Practice By Eghianruwa K, Author House, 2014, page no. 271.
https://books.google.co.in/books?id=h4zCAgAAQBAJ&pg=PA271 |
| 4. |
Chapter 14: Pharmacology and Therapeutics in Gynecologic Cancer by Alberts DS et al ; In : Principles and Practice of Gynecologic Oncology 6th edition
By Barakat R et al, Lippincott Williams & Wilkins, 2013, page no. 1319.
https://books.google.co.in/books?id=7QbZCx5d-zoC&pg=PT1319 |
| 5. |
Spittle MF, Methotrexate and radiation. Int J Radiat Oncol Biol Phys. 1978 ;4(1-2):103-7.
http://dx.doi.org/10.1016/0360-3016(78)90123-2
|
| 6. |
Methotreaxate; In : Hazardous Laboratory Chemicals Disposal Guide, Third Edition
By Armour MA, CRC Press,2016, page no. 304.
https://books.google.co.in/books?id=bLV55kunjA4C&pg=PA304 |
