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Melphalan

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GENERAL FEATURES

Name: Melphalan
Synonyms:
Trade name: Alkeran®[1],[2]
Chemical name: It is a nitrogen mustard attached to phenylalanine moiety[3],[4]
4-[bis(2-chloroethyl)-amino]-L-phenylalanine[3]
Molecular Weight: 305.20 g/mol[2]
Source:
Structure: [3],[1],[2],[4]
Chemical Nature: It is practically insoluble in water, insoluble in chloroform and ether, slightly soluble in methanol, soluble in ethanol, propylene glycol.[5]
Actions
& Indications:
Pharmcological Action-
functions as alkylating agent in physiological conditions[2]
Therapeutic indications:
Preclinical study-
REFERENCES
1. Chapter 3. DNA-Interactive agents; In : Chemistry and Pharmacology of Anticancer Drugs, by Thurston DE, CRC Press, 2006, page no. 52.
https://books.google.co.in/books?id=6mPLBQAAQBAJ&pg=PA52
2. Melphalan by Feyns LV ; In : Profiles of Drug Substances, Excipients and Related Methodology, vol. 13, edited by Florey K, Academic Press, 1984, page no. 265.
https://books.google.co.in/books?id=Fz6X-GmS-GgC&pg=PA265
3. Chapter 2. Chemotherapeutic Agents Used in the Treatment of Gynecologic Malignancies by DuPont J et al ; In : Chemotherapy of Gynecologic Cancers: Society of Gynecologic Oncologists Handbook edited by Rubin SC, Lippincott Williams & Wilkins, 2004, page no. 36.
https://books.google.co.in/books?id=9P-KjU-9BRIC&pg=PA36
4. 7. Alkylating Agents by Boddy AV ; in : Cancer Clinical Pharmacology edited by Schellens JHM, McLeod HL, Newell DR, OUP Oxford, 2005, page no. 90.
https://books.google.co.in/books?id=co8Sgu9N0FMC&pg=PA90
5. Melphalan ; In : Report on Carcinogens (12th Ed.) by Nat. Toxicology Program (NTP) (NIH), DIANE Publishing, 2011, page no. 258.
https://books.google.co.in/books?id=raW5FLj408QC&pg=PA258