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"Radiosensitisers and Radioprotectors"

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Name: Lycopene
Trade name: lyc-o-mato lycopene®, GNC product[1]
Ixor® (contains Resveratrol, Lycopene, Vitamin C and anthocianin)[13]
Source: bioactive carotenoid present in many fruits and vegetables, tomatoes are the major source.[2]
abundant in red fruits[1]
watermelons, pink grapefruits, apricots, pink guavas and papaya[3],[4]
Chemical Nature: Lycopene is an acyclic isomer of beta-carotene. Lycopene is a highly unsaturated hydrocarbon containing 11 conjugated and 2 unconjugated double bonds.[8]
Eleven conjugated double bonds of lycopene give it a deep red color and are responsible for its antioxidant activity[9]
& Indications:
Pharmcological Action-
in vivo antioxidant[2]
anti-inflammatory in rats[10]
anti-atherogenic in rats[11]
Preclinical study-
It is demonstrated to be an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers in clinical setting[12]
1. Acar DE et al, Reducing the histopathological changes of Radioiodine to the lacrimal glands by a popular anti-oxidant: lycopene.Current Eye Research 2014; 39(7): 659–665.
2. Agarwal A et al, Lycopene content of tomato products: its stability, bioavailability and in vivo antioxidant properties. J Med Food. 2001;4(1):9-15.
3. Stahl W, Sies H, Lycopene: a biologically important carotenoid for humans? Archives of Biochemistry and Biophysics. 1996;336(1):1–9.
4. 5 : Lycopene Bioavailability and its effect on health by Ferreira ALA, Correa CR; In: Part I: Food Quality; In :Food Quality, Safety and Technology, edited by Lima GPP, Vianello F, Springer, Page no. 69.
5. Camacho-Alonso F, López-Jornet P, Tudela-Mulero MR, Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells. Oral Diseases 2013; 19: 465-472.
6. Mathew-Roth MM et al, Distribution of [14C]Canthaxanthin and [14C]Lycopene in rats and monkeys. J. Nutr. 1990;120(10):1205-1213.
7. Saad TMM, Proactive role of garlic and lycopene extract against Gamma irradiation-induced alterations in antioxidant defense systems in the brain of rats. The Egyptian Journal of Hospital Medicine 2012;46 :17– 25.
8. Gajowik A, Dobrzyńska MM, Lycopene - antioxidant with radioprotective and anticancer properties. A review. Rocz Panstw Zakl Hig. 2014;65(4):263-71.
9. Pirayesh Islamian J, Mehrali H, Lycopene as a carotenoid provides radioprotectant and antioxidant effects by quenching radiation-induced free radical singlet oxygen: an overview. Cell J. 2015; 16(4): 386-391.
10. Bignotto L et al, Antiinflammatory effect of lycopene on carrageenaninduced paw oedema and hepatic ischaemiareperfusion in the rat. Br J Nutr. 2009;102(1):126-33.
11. Liu X et al, Effect of lycopene on the vascular endothelial function and expression of inflammatory agents in hyperhomocysteinemic rats. Asia Pac J Clin Nutr. 2007;16 Suppl 1:2448.
12. Misra R et al, LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial. J Obstet Gynaecol Res. 2006;32(3):299-304.
13. Di Franco R et al, Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®). Radiat Oncol. 2012;7:12.