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Glyzyrrhizic acid

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Name: Glyzyrrhizic acid
Synonyms: glycyrrhizinic acid[1]
Trade name:
Chemical name:
Molecular Weight: 823 g/mol[1]
Source: Glyzyrrhizic acid is a natural component of licorice, isolated from dried roots of glycyrrhiza glabra.[1]
Structure: [2],[3],[4]
Chemical Nature:
& Indications:
Pharmcological Action-
anti-inflammatory in mice[6]
Therapeutic indications:
Clinical trials for its use in treatment of chronic hepatitis C has been conducted.[5]
Preclinical study-
1. 3. Physical nd Chemical Properties of Glycyrhizzic acid; In : Adverse Health Effects of Glycyrrhizic Acid in Licorice, by Størmer FC, Nordic Council of Ministers, 1994, page no. 8.
2. Chapter 78. Licorice; In : Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals by Barceloux DG, John Wiley & Sons, 2012.
3. Phenolic Constituents of Licorice(Glycyrrhiza species) by Nomura T, Fukai T ; In : Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry, Springer Science & Business Media, 2012.
4. Licorice(Glycyrrhiza glabra) by Armanini D et al ;In : Encyclopedia of Dietary Supplements, edited by Coates PM et al, CRC Press, 2004, page no. 393.
5. Van TGJ et al, glycyrrhizin as a potential treatment for chronic hepatitis C. Alimentary Pharmacology and Therapeutics 1998;12(3):199–205.
6. Yu JY et al, Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver. Molecules. 2015;20(7):13041-54.
7. Cosmetic Ingredient Review Expert Panel, Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate. Int J Toxicol. 2007;26 Suppl 2:79-112.