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"Radiosensitisers and Radioprotectors"

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Ferulic acid

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GENERAL FEATURES

Name: Ferulic acid
Synonyms:
Trade name:
Chemical name: 3-methoxy-4-hydroxycinnamic acid[1]
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid[2]
Molecular Weight: 194.2 g/mol[3]
Source: Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. It occurs primarily in seeds and leaves both in its free form and covalently linked to lignin and other biopolymers.[4]
Structure: [5],[6],[7],[8]
Chemical Nature:
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Karthikeyan S et al, Radiosensitizing effect of ferulic acid on human cervical carcinoma cells in vitro. Toxicol In Vitro. 2011;25(7):1366-75.
http://dx.doi.org/10.1016/j.tiv.2011.05.007
2. Paiva L et al, Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field. Braz J Pharm Sci 2013;49(3):395-411.
http://dx.doi.org/10.1590/S1984-82502013000300002
3. Ohta S, Furukawa M, Shinoda M, Studies on chemical protectors against radiation. XXIII. Radioprotective activities of ferulic acid and its related compounds. Yakugaku Zasshi 1984;104(7):793-797.
https://www.jstage.jst.go.jp/article/yakushi1947/104/7/104_7_793/_pdf
4. Graf E, Antioxidant potential of ferulic acid. Free Radic Biol Med. 1992 ;13(4):435-48.
http://dx.doi.org/10.1016/0891-5849(92)90184-I
5. Ma ZC et al, Ferulic acid protects lymphocytes from radiation-predisposed oxidative stress through extracellular regulated kinase. Int J Radiat Biol. 2011;87(2):130-40.
http://dx.doi.org/10.3109/09553002.2011.523510
6. Maurya DK, Salvi VP, Nair CK, Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions. Mol Cell Biochem. 2005;280(1-2):209-17.
http://dx.doi.org/10.1007/s11010-005-0170-4
7. Maurya DK, Nair CK, Preferential radioprotection to DNA of normal tissues by ferulic acid under ex vivo and in vivo conditions in tumor bearing mice. Mol Cell Biochem. 2006;285(1-2):181-90.
http://dx.doi.org/10.1007/s11010-005-9079-1
8. Shanthakumar J et al, Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice. Eur J Pharmacol. 2012;691(1-3):268-74.
http://dx.doi.org/10.1016/j.ejphar.2012.06.027