| Name: |
Etanidazole |
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| Synonyms: |
SR-2508, DuP 435[1]
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| Trade name: |
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| Chemical name: |
(N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide[1]
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| Molecular Weight: |
214 g/mol[2],[3]
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| Source: |
|
| Structure: |
 [1],[4]
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| Chemical Nature: |
Etanidazole is soluble in water[1]
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| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
Preclinical study-
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| Analogues: |
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| REFERENCES |
| 1. |
Maurin MB et al, Solubility behaviour, phase transition, and structure-based nucleationinhibition of etanidazole in aqueous solutions. Pharmaceutical Research 1996;13(9):1401-1405.
https://dx.doi.org/10.1023/A:1016038403921 |
| 2. |
Newman HF et al, Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole). Int J Radiat Oncol Biol Phys. 1988;15(3):677-84.
http://dx.doi.org/10.1016/0360-3016(88)90311-2
|
| 3. |
White RAS, Workman P, Brown JM, The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog-hydrophilic radiosensitizers potentially less toxic than misonidazole. Radiation Research 1980;84(3):542-561.
http://dx.doi.org/10.2307/3575492 |
| 4. |
Jin C et al, Radiosensitization of paclitaxel, etanidazole and paclitaxel + etanidazole
nanoparticles on hypoxic human tumor cells in vitro. Biomaterials 2007;28: 3724–3730.
http://dx.doi.org/10.1016/j.biomaterials.2007.04.032 |
