Welcome to University of Mumbai, Department of Biophysics


Bioinformatics Database on
"Radiosensitisers and Radioprotectors"

Alphabetical Search   >  E   >  Etanidazole                                                                                                                                                                 Top

Etanidazole

Go To:


General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


GENERAL FEATURES

Name: Etanidazole
Synonyms: SR-2508, DuP 435[1]
Trade name:
Chemical name: (N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide[1]
Molecular Weight: 214 g/mol[2],[3]
Source:
Structure: [1],[4]
Chemical Nature: Etanidazole is soluble in water[1]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
Preclinical study-
Analogues:
REFERENCES
1. Maurin MB et al, Solubility behaviour, phase transition, and structure-based nucleationinhibition of etanidazole in aqueous solutions. Pharmaceutical Research 1996;13(9):1401-1405.
https://dx.doi.org/10.1023/A:1016038403921
2. Newman HF et al, Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole). Int J Radiat Oncol Biol Phys. 1988;15(3):677-84.
http://dx.doi.org/10.1016/0360-3016(88)90311-2
3. White RAS, Workman P, Brown JM, The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog-hydrophilic radiosensitizers potentially less toxic than misonidazole. Radiation Research 1980;84(3):542-561.
http://dx.doi.org/10.2307/3575492
4. Jin C et al, Radiosensitization of paclitaxel, etanidazole and paclitaxel + etanidazole nanoparticles on hypoxic human tumor cells in vitro. Biomaterials 2007;28: 3724–3730.
http://dx.doi.org/10.1016/j.biomaterials.2007.04.032