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Edaravone

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GENERAL FEATURES

Name: Edaravone
Synonyms: MCI-186[1]
Trade name: Radicut®[2]
Chemical name: 3-Methyl-1-phenyl-2-pyrazolin-5-one[1],[2]
Molecular Weight: 174.20 g/mol[3]
Source:
Structure: [3],[1]
Chemical Nature: At physiological pH, edaravone exists in an anionic form.[1]
Actions
& Indications:
Pharmcological Action-
neuroprotective[4]
antioxidant[5]
Therapeutic indications:
Preclinical study-
Notes: Edaravone decreased the body temperature transiently about 3-6oC. [2]
REFERENCES
1. Abe S et al, The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical. Chem Pharm Bull (Tokyo). 2004;52(2):186-91.
http://doi.org/10.1248/cpb.52.186
2. Anzai K et al, In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug. J Radiat Res 2004; 45 (2): 319-323.
http://dx.doi.org/10.1269/jrr.45.319
3. Edaravone ; In : HPLC Methods for Recently Approved Pharmaceuticals By Lunn G, John Wiley & Sons, 2005, page no. 204.
https://books.google.co.in/books?id=tWum1pbwKmMC&pg=PA204
4. Yoshida H et al, Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev. 2006;12(1):9-20.
http://dx.doi.org/10.1111/j.1527-3458.2006.00009.x
5. Yamamoto Y et al, Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one. Redox Rep. 1996;2(5):333-8.
http://dx.doi.org/10.1080/13510002.1996.11747069