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Dieckol & Eckol

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Name: Dieckol & Eckol
Generic name:
IUPAC name:
Trade name: Seanol® is a polyphenol extract derived from a brown alga, Ecklonia cava, consists of phlorotannins including eckol and dieckol.[1]
Source: Eckol is a component of brown seaweed Ecklonia cava[2]
Dieckol can be isolated from the brown alga Eisenia bicyclis[3]
Structure: Dieckol :
Eckol :
Chemical Nature: both eckol and dieckol are brown algal phlorotannins[8],[9]
Eckol has dibenzo-1,4-dioxin skeleton[10]
The intrinsic stability of phenolic structures is suggested to be related to antioxidative activity of eckol[11]
& Indications:
Pharmcological Action-
Antithrombotic and profibrinolytic activity is possessed by both eckol and dieckol[12]
Dieckol is antidiabeti in diabetic mouse model[13]
Preclinical study-
Diekol is shown to stimulate hair growth in a animal model[14]
In a clinical study, efficacy of dieckol in treatment of diabetes is demonstrated[15]
1. Choi HS et al, Seanol® and its major compound, dieckol suppress lipid accumulation during adipogenesis through inhibition of Mitotic Clonal Expansion (MCE) and cell cycle arrest. The FASEB Journal. 2013; 27 ( 1 Supplement).
2. Park E et al, Radioprotective properties of eckol against ionizing radiation in mice. FEBS Letters 2008;582: 925–930.
3. Fujii Y et al, Evaluation for antioxidative properties of Phlorotannins isolated from the brown alga Eisenia bicyclis, by the H-ORAC Method. Food and Nutrition Sciences 2013; 4: 78-82.
4. Park E et al, Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. Int. J. Radiat. Biol. 2010;86(10): 848–859.
5. Shibata T et al, Inhibitory effects of brown algal phlorotannins on secretory phospholipase A2s, lipoxygenases and cyclooxygenases. Journal of Applied Phycology 2003;15: 61–66.
6. Wang H, Fu ZM, Han CC, The potential applications of marine bioactives against diabetes and obesity. American Journal of Marine Science 2014;2(1):1-8.
7. Zhang R et al, Eckol protects V79-4 lung fibroblast cells against γ-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH2-terminal kinase pathway. European Journal of Pharmacology 2008;591: 114–123.
8. Nineteenth International Seaweed Symposium: Proceedings of the 19th International Seaweed Symposium held in Kobe, Japan, 2007, edited by Borowitzka MA et al, Springer, page no. 259.
9. Ahn GN et al, Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage. Eur Food Res Technol 2007;226:71–79.
10. Fukuyama Y et al, Structure of an anti-plasmin inhibitor, eckol, isolated from the brown alga Ecklonia kurome Okamura and inhibitory activities of its derivatives on plasma plasmin inhibitors. Chem Pharm Bull (Tokyo). 1989 ;37(2):349-53.
11. Kang KA et al, Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Letters 2005;579: 6295–6304.
12. Kim TH, Ku SK, Bae JS, Antithrombotic and profibrinolytic activities of eckol and dieckol. J Cell Biochem. 2012;113(9):2877-83.
13. Kang MC et al, Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food Chem Toxicol. 2013;53:294-8.
14. Kang JI et al, Effect of Dieckol, a component of Ecklonia cava, on the promotion of hair growth. Int. J. Mol. Sci. 2012; 13:6407-6423.
15. Lee SH, Jeon YJ, Efficacy and safety of a dieckolrich extract (AGdieckol) of brown algae, Ecklonia cava, in prediabetic individuals: a doubleblind, randomized, placebocontrolled clinical trial. Food Funct. 2015;6(3):853-8.