| Name: |
Balsalazide |
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| Synonyms: |
BX 661A, balsalazine, balsalazide disodium[1]
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| Trade name: |
Colazal®,
Salix Pharmaceuticals, Inc., Morrisville, NC, USA[2]
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| Chemical name: |
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| Molecular Weight: |
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| Source: |
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| Structure: |
 [1],[3]
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| Chemical Nature: |
Balsalazide is a prodrug of mesalazine which has
an inert carrier molecule instead of the sulfapyridine
moiety of sulfasalazine.[1]
|
| Actions & Indications: |
Pharmcological Action-
Therapeutic indications:
In a clinical study, balsalazide improved the signs and symptoms of mild-tomoderate
ulcerative colitis in pediatric patients 5 to 17 years of age.[2]
Preclinical study-
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| Notes: |
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| REFERENCES |
| 1. |
Prakash A, Spencer CM, Balsalazide, Adis International Limited, Auckland, New Zealand. Drugs 1998; 56 (1): 83-89.
http://dx.doi.org/10.2165/00003495-199856010-00008 |
| 2. |
Quiros JA et al, Safety, efficacy, and pharmacokinetics of Balsalazide in
pediatric patients with mild-to-moderate active ulcerative
colitis: results of a randomized, double-blind study. Pediatr Gastroenterol Nutr. 2009; 49(5): 571–579.
http://dx.doi.org/10.1097/MPG.0b013e31819bcac4 |
| 3. |
6. Oral Mesalamine by Sakuraba A; In : Medical Therapy of Ulcerative Colitis edited by Lichtenstein GR, Springer, 2014, page no. 57.
https://books.google.co.in/books?id=FDugBQAAQBAJ&pg=PA57 |
