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Balsalazide

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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GENERAL FEATURES

Name: Balsalazide
Synonyms: BX 661A, balsalazine, balsalazide disodium[1]
Trade name: Colazal®, Salix Pharmaceuticals, Inc., Morrisville, NC, USA[2]
Chemical name:
Molecular Weight:
Source:
Structure: [1],[3]
Chemical Nature: Balsalazide is a prodrug of mesalazine which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine.[1]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
In a clinical study, balsalazide improved the signs and symptoms of mild-tomoderate ulcerative colitis in pediatric patients 5 to 17 years of age.[2]
Preclinical study-
Notes:
REFERENCES
1. Prakash A, Spencer CM, Balsalazide, Adis International Limited, Auckland, New Zealand. Drugs 1998; 56 (1): 83-89.
http://dx.doi.org/10.2165/00003495-199856010-00008
2. Quiros JA et al, Safety, efficacy, and pharmacokinetics of Balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study. Pediatr Gastroenterol Nutr. 2009; 49(5): 571–579.
http://dx.doi.org/10.1097/MPG.0b013e31819bcac4
3. 6. Oral Mesalamine by Sakuraba A; In : Medical Therapy of Ulcerative Colitis edited by Lichtenstein GR, Springer, 2014, page no. 57.
https://books.google.co.in/books?id=FDugBQAAQBAJ&pg=PA57