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Asparagus racemosus

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GENERAL FEATURES

Name: Asparagus racemosus
Synonyms/Scientific names: Asparagus racemosus Willd[1]
Synonyms/common names :
Shataavari[1]
English name: Indian Asparagus[1]
Trade name:
One of the constituents of "geriforte" powder (Himalaya Drug Co., Bangalore, India)[2]
It is also a constituent of "Dhatriyadi Yoga"[3], and "abana" (Himalaya Drug Co., Bangalore, India)[4]
Shatavari[5]
Description: Family : Asparagaceae (Liliaceae)[6],[1]
Extract used:
Phyto-constituents
(active):
roots
quercetin[7]
Shatavarin - I[8]
Shatavarin - IV[9]
Shatavarin V[10]
Asparagamine A[11]
Actions
& Indications:
Pharmcological Action-
hepatoprotective in rats[12],[13]
Antiulcer activity in rats[14]
Antidepressant-like activity in mice
[15], in rats[16]
Anticonvulsant in mice[7]
Therapeutic indications:
Root is used in treatment of diarrhoea, dysentry, skin diseases, dyspepsia, rheumatism and to stimulate appetite[17]
Preclinical study-
Aqueous extract of roots of Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity.[18]
A clinical study concluded that A. racemosus exhibited significant galactogogue activity in lactating mothers[19]; while another study showed controversial results[20]
Notes:
REFERENCES
1. 3.9 : Satavar ;in : Part II: Medicinal Importance of Climbers used in Unani System of Medicine by Kalam MA, Ahmad G; In : Biotechnological strategies for the conservation of medicinal and ornamental Climbers, edited by Shahzad A, Sharma S, Siddiqui S, Springer, 2015, Page no. 88.
https://books.google.com/books?id=cERECwAAQBAJ&pg=PA88
2. Chapter 5 : Immunomodulation : Therapeutic Strategy through Ayurveda by Mungantiwar AA, Phadke AS, Scientific Basis for Ayurvedic Therapies, edited by Mishra LC, CRC Press, 2003, Page no. 70.
https://books.google.com/books?id=qo0VPGr0RF4C&pg=PA70
3. Shatawari (Asparagus racemosus) ; In : Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation by Puri HS, tailor & Francis, 2003, Page no. 260.
https://books.google.com/books?id=ekjtVOppIxwC&pg=PA260
4. 18 : Ashwagandha ; In :The Complete Book on Jatropha (Bio-Diesel) with Ashwagandha, Stevia, Brahmi & Jatamansi Herbs (Cultivation, Processing & Uses), by NIIR Board of Consultants and Engineers, Asia Pacific Business Press Inc., 2008, Page no. 316.
https://books.google.com/books?id=LfXKAgAAQBAJ&pg=PA316
5. 3 : Herbs in Arunachal Pradesh: An exploration for economic viability and sustainability by Chobin D, Rural Development in North East India, edited by Singha K, Patikar G, Concept Publishing Company, 2010, page no. 50.
https://books.google.com/books?id=cvMgERDpbIIC&pg=PA50
6. 18 : Phytochemistry of plants used in Traditional medicine, by Gonzalez-Stuart AE, Prakash D, Gupta C ; In: Phytochemicals of Nutraceutical Importance, edited by Prakash D, Sharma G, CABI, 2014, Page no. 302.
https://books.google.com/books?id=JqANAwAAQBAJ&pg=PA302
7. Shastry RA et al, Phytochemical investigation and antiepileptic activity of Asparagus racemosus (Wild) root extracts in rodents. RGUHS J Pharm Sci 2015;5(3): 97-103.
http://dx.doi.org/10.5530/rjps.2015.3.3
8. Joshi J, Dev S, Chemistry of ayurvedic crude drugs: Part VIII: Shatavari: 2. Structure elucidation of bioactive shatavarin-I and other glycosides. ChemInform abstracts 1988;19(28):Abstract no. 228.
http://dx.doi.org/10.1002/chin.198828228
9. Gohel R et al, Isolation and characterization of Shatavarin IV from root of Asparagus racemosusWilld. International Journal of Pharmacy and Pharmaceutical Sciences. 2015;7(6):362-365.
http://innovareacademics.in/journals/index.php/ijpps/article/view/5324
10. Hayes PY et al, Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus. Tetrahedron Letters. 2006; 47(49):8683-8687.
http://dx.doi.org/10.1016/j.tetlet.2006.10.030
11. Sekine T et al, Structure of Asparagamine A, a novel polycyclic alkaloid from Asparagus racemosus. Chem. Pharm. Bull. 1994;42(6):1360-1362.
http://doi.org/10.1248/cpb.42.1360
12. Acharya SR et al, Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts. Indian Journal of Experimental Biology 2012;50(11):795-801.
http://www.ncbi.nlm.nih.gov/pubmed/23305030
13. Rahiman F, Musambil M, Shejina M, Hepatoprotective Activity of Asparagus racemosus Root against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats. Int. J. Pharm. Sci. Rev. Res. 2015;30(1): 169-172.
http://globalresearchonline.net/journalcontents/v30-1/30.pdf
14. Bhatnagar M, Sisodia SS, Bhatnagar R, Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats. Ann N Y Acad Sci. 2005;1056:261-78.
http://dx.doi.org/10.1196/annals.1352.027
15. Dhingra D, Kumar V, Pharmacological evaluation for antidepressant-like activity of Asparagus racemosus Willd. in mice. Pharmacologyonline 2007;3: 133-152.
http://pharmacologyonline.silae.it/files/archives/2007/vol3/11_Dhingra.pdf
16. Singh GK et al, Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol Biochem Behav. 2009;91(3):283-90.
http://dx.doi.org/10.1016/j.pbb.2008.07.010
17. 68 : Asparagus racemosus ; in :Handbook On Medicinal Herbs With Uses, by Panda H, Asia Pacific Business Press Inc., 2004, Page no. 86.
https://books.google.com/books?id=VRKmAwAAQBAJ&pg=PT86
18. Kumar MC et al, Acute toxicity and diuretic studies of the roots of Asparagus racemosus Willd in rats. West Indian Med J 2010; 59 (1): 3-6.
http://caribbean.scielo.org/scielo.php?script=sci_arttext&pid=S0043-31442010000100002
19. Gupta M, Shaw B, A double-blind randomized clinical trial for evaluation of galactogogue activity of Asparagus racemosus Willd. Iranian Journal of Pharmaceutical Research 2011; 10 (1): 167-172.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869575/
20. Sharma S et al, Randomized controlled trial of Asparagus racetnosus (Shatavari) as a lactogogue in lactational inadequacy. Indian Pediatr. 1996;33(8):675-7.
http://www.indianpediatrics.net/aug1996/675.pdf