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Artesunate

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GENERAL FEATURES

Name: Artesunate
Trade name:
Chemical name: (3R, 5aS, 6R, 8aS, 9R, 10S, 12R, 12aR)- Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, hydrogen succinate[1]
Artesunato, Cotecxin, Larinate[2]
Molecular Weight: 384.4 g/mol[3]
Source:
Structure: [1],[4],[3],[5]
Chemical Nature: Artesunate is a sodium salt of the hemisuccinate ester of artemisinin.[3]
It is soluble in water, poor stability in aqueous solution at neutral or acid pH.[3]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
Artesunate is used for the treatment of severe Falciparum malaria.[6]
Preclinical study-
Notes:
REFERENCES
1. The International Pharmacopoeia, Fourth Edition, Volume 1, by World Health Organization, World Health Organization, 2006, page no. 124.
https://books.google.co.in/books?id=s_sBKJNf184C&pg=PA124
2. Artemisinin ; In : Analytical Methods for Therapeutic Drug Monitoring and Toxicology, by Xu QA, Madden TL, John Wiley & Sons, 2011, page no. 47.
https://books.google.co.in/books?id=TJeIXZhk-4kC&pg=PA47
3. Annex 3. Pharmacology of Antimalarial Medicines ; In : Guidelines for the Treatment of Malaria, by World Health Organization, World Health Organization, 2010, page no. 83.
https://books.google.co.in/books?id=R-MOrOvUkB8C&pg=PA83
4. Chapter 19. Antimalarials ; In : Medicinal Chemistry by Kar A, New Age International, 2005, page no. 567.
https://books.google.co.in/books?id=07g30rxCA0EC&pg=PA567
5. Pharmaceutical Sciences: Breakthroughs in Research and Practice: Breakthroughs in Research and Practice by Management Association, Information Resources IGI Global, 2016, page no. 435.
https://books.google.co.in/books?id=5DfVDQAAQBAJ&pg=PA435
6. Rosenthal PJ et al, Artesunate for the Treatment of Severe Falciparum Malaria. N Engl J Med 2008; 358:1829-1836.
http://dx.doi.org/10.1056/NEJMct0709050