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Name: Artemisinin
Trade name:
Chemical name: 3,6,9-trimethyl-9,10b-epidioxyperhydropyrano[4,3,2-ik]benzoxepin-2-one.[1]
(3α, 5αβ, 6β, 8αβ, 9α, 12β, 12aR)-(+)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one[2]
Molecular Weight: 282.3 g/mol[3]
Source: Artemisinin, also know as ginghaosu, is compound found from leaves of Artemisia annua , commonly called as Sweet wormwood.[3]
Structure: [5],[4],[3],[6],[7]
Chemical Nature: Its a sesquiterpene lactone[3]
Artemisinin is poorly soluble in oil as well as in water[8],[7]
& Indications:
Pharmcological Action-
Therapeutic indications:
It is, traditionally, used to treat fever, chills and malaria.[7],[9]
Preclinical study-
1. 7.9 Artemisinin: A Sesquiterpene Lactone with Endoperoxide Linkage and Profound Antimalarial Activity; In : Chemistry of Plant Natural Products: Stereochemistry, Conformation, Synthesis, Biology, and Medicine, Talapatra SK, Talapatra B, Springer, 2015, page no. 447.
2. Chapter 19. Antimalarials ; In : Medicinal Chemistry, Third edition, by Kar A, New Age International, 2005, page no. 567.
3. 13. Mass drug administration; In : Guidelines for the Treatment of Malaria, Second Edition, by World Health Organization, World Health Organization, 2010, page no. 80.
4. Artemisinin Regulation of Proliferation and Disruption of Androgen Responsiveness of Human Prostate Cancer Cells. A thesis submitted by Willoughby JA to University of California, Berkeley, ProQuest, 2007,
5. Medhi B et al, Pharmacokinetic and toxicological profile of Artemisinin compounds: an update. Pharmacology 2009;84:323–332 .
6. 1. Production of Artemisinin from in vitro cultures of Artemisia annua L. by Ferreira JFS, Janick J; In :Bioechnology in Agriculture and Forestry 51. Medicinal and Aromatic Plants XII, edited by Nagata T, Ebizuka Y, Springer Science & Business Media, 2002, page no. 2.
7. 9. Structure-Activity Relationships of Peroxide-Based Artemisinin Antimalarials by Avery MA et al; In : Biologically Active Natural Products: Pharmaceuticals edited by Cutler SJ, Cutler HG, CRC Press, 1999, page no. 56.
8. Titulaer HAC et al, The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol. 1990;42(11):810-3.
9. Artemisia annua ; In : Encyclopedia Of Herbal Medicine, by Chevallier A, Dorling Kindersley Ltd, 2016, page no. 67.