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Artemisinin

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GENERAL FEATURES

Name: Artemisinin
Trade name:
Chemical name: 3,6,9-trimethyl-9,10b-epidioxyperhydropyrano[4,3,2-ik]benzoxepin-2-one.[1]
(3α, 5αβ, 6β, 8αβ, 9α, 12β, 12aR)-(+)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one[2]
Molecular Weight: 282.3 g/mol[3]
Source: Artemisinin, also know as ginghaosu, is compound found from leaves of Artemisia annua , commonly called as Sweet wormwood.[3]
Structure: [5],[4],[3],[6],[7]
Chemical Nature: Its a sesquiterpene lactone[3]
Artemisinin is poorly soluble in oil as well as in water[8],[7]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
It is, traditionally, used to treat fever, chills and malaria.[7],[9]
Preclinical study-
Notes:
REFERENCES
1. 7.9 Artemisinin: A Sesquiterpene Lactone with Endoperoxide Linkage and Profound Antimalarial Activity; In : Chemistry of Plant Natural Products: Stereochemistry, Conformation, Synthesis, Biology, and Medicine, Talapatra SK, Talapatra B, Springer, 2015, page no. 447.
https://books.google.co.in/books?id=d8IPBwAAQBAJ&pg=PA447
2. Chapter 19. Antimalarials ; In : Medicinal Chemistry, Third edition, by Kar A, New Age International, 2005, page no. 567.
https://books.google.co.in/books?id=07g30rxCA0EC&pg=PA567
3. 13. Mass drug administration; In : Guidelines for the Treatment of Malaria, Second Edition, by World Health Organization, World Health Organization, 2010, page no. 80.
https://books.google.co.in/books?id=R-MOrOvUkB8C&pg=PA80
4. Artemisinin Regulation of Proliferation and Disruption of Androgen Responsiveness of Human Prostate Cancer Cells. A thesis submitted by Willoughby JA to University of California, Berkeley, ProQuest, 2007,
https://books.google.co.in/books?id=onSkSNVVl_kC&pg=PR21
5. Medhi B et al, Pharmacokinetic and toxicological profile of Artemisinin compounds: an update. Pharmacology 2009;84:323–332 .
http://dx.doi.org/10.1159/000252658
6. 1. Production of Artemisinin from in vitro cultures of Artemisia annua L. by Ferreira JFS, Janick J; In :Bioechnology in Agriculture and Forestry 51. Medicinal and Aromatic Plants XII, edited by Nagata T, Ebizuka Y, Springer Science & Business Media, 2002, page no. 2.
https://books.google.co.in/books?hl=en&lr=&id=MSfOKBWv_sIC&oi=fnd&pg=PA2
7. 9. Structure-Activity Relationships of Peroxide-Based Artemisinin Antimalarials by Avery MA et al; In : Biologically Active Natural Products: Pharmaceuticals edited by Cutler SJ, Cutler HG, CRC Press, 1999, page no. 56.
https://books.google.co.in/books?id=yUY_iDQcD-AC&pg=SA5-PA56
8. Titulaer HAC et al, The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol. 1990;42(11):810-3.
http://dx.doi.org/10.1111/j.2042-7158.1990.tb07030.x
9. Artemisia annua ; In : Encyclopedia Of Herbal Medicine, by Chevallier A, Dorling Kindersley Ltd, 2016, page no. 67.
https://books.google.co.in/books?id=vzBIDAAAQBAJ&pg=PA67