| Name: |
Andrographis paniculata |
|---|
| Synonyms/Scientific names: |
Andrographis paniculata (Burm f.) Nees[1]
Synonyms/common names :
Andrographis, Green chirayta, creat, king of bitters,Kalmegh, Kalamegha[1]
English name:
Trade name:
Kan Jang®, a herbal preparation containg extract of A. panculata[2]
|
|---|
| Description: |
Family : Acanthaceae[1]
|
| Extract used: |
|
| Phyto-constituents(active): |
5,7,2',3'-tetramethoxyflavanone and 5-hydroxy-7,2',3'-trimethoxyflavone, andrographolide diterpenoids, and polyphenols[3]
7-O-methylwogonin , 7-O-methyldihydrowogonin , 5-hydroxy-7, 8, 2', 5'-tetramethoxy-flavone , skullcapflavone-2'-methoxylether , 5-hydroxy-7, 8, 2', 3'-tetramethoxyflavone , 5, 4'-dihydroxy-7, 8, 2', 3'-tetramethoxyflavone, dihydroskullcapflavone , 5, 7, 8-trimethoxydihydroflavone , 5, 2'-dihydroxy-7, 8-dimethoxyflvone , andrographidine C , 5, 7, 4'-trihydroxyflavone , 5, 7, 3', 4'-tetrahydroxyflavone[4]
Aerial parts:
neoandrographolide, 3, 14-di-deoxyandrographolide , andrographolide, 14-deoxy-11, 12-didehydroandrographolide, 19-hydroxy-8 (17), 13-labdadien-15, 16-olide, 14-deoxy-andrographolide , 3-oxo-14-deoxy-andrographolide , isoandrographolide , bisandrographolide , deoxyandrographiside , 14-deoxy-11, 12-didehydroandrographiside, andrographiside[5]
3-O-beta-D-glucosyl-14-deoxyandrographiside and 3-O-beta-D-glucosyl-14-deoxy-11,12-didehydroandrographiside[6]
|
| Actions & Indications: |
Pharmcological Action-
hepatoprotective in mice[7]
antioxidant and anti-inflammatory in mice[8]
analgesic in rats[9]
antidiabetic in rats[10]
Therapeutic indications:
Preclinical study-
|
| Notes: |
|
| REFERENCES |
| 1. |
Chapter 3 : Pharmacognostical Profile of Selected Medicinal Plants ; In :Handbook of African Medicinal Plants, Second Edition, by Iwu MM, CRC Press, 2014, Page no. 140.
https://books.google.com/books?id=GictAgAAQBAJ&pg=PA140 |
| 2. |
Spasov AA et al, Comparative controlled study of Andrographis fixed
combination, Kan Jang® and an Echinacea preparation as adjuvant, in the
treatment of uncomplicated respiratory disease in children. Phytother Res.
2004;18(1):47–53.
http://dx.doi.org/10.1002/ptr.1359 |
| 3. |
Koteswara Rao Y et al, Flavonoids and andrographolides from Andrographis paniculata. Phytochemistry. 2004;65(16):2317-21.
http://dx.doi.org/10.1016/j.phytochem.2004.05.008 |
| 4. |
Chen LX, Qu GX, Qiu F, Studies on flavonoids of Andrographis paniculata. Zhongguo Zhong Yao Za Zhi. 2006 ;31(5):391-5.
http://www.ncbi.nlm.nih.gov/pubmed/16711423 |
| 5. |
Chen LX, Qu GX, Qiu F, Studies on diterpenoids from Andrographis paniculata. Zhongguo Zhong Yao Za Zhi. 2006 ;31(19):1594-7.
http://www.ncbi.nlm.nih.gov/pubmed/17165582 |
| 6. |
Zhou KL et al, Two new entlabdane
diterpenoid glycosides from the aerial parts of
Andrographis paniculata. J Asian Nat Prod Res. 2008 ;10(
9-10):939-43.
http://dx.doi.org/10.1080/10286020802217432 |
| 7. |
Nagalekshmi R et al, Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food Chem Toxicol. 2011;49(12):3367-73.
http://dx.doi.org/10.1016/j.fct.2011.09.026 |
| 8. |
Sheeja K, Shihab PK, Kuttan G, Antioxidant and anti-inflammatory
activities of the plant Andrographis
Paniculata Nees. Immunopharmacology and Immunotoxicology 2006;28(1):129-140.
http://dx.doi.org/10.1080/08923970600626007 |
| 9. |
Tanweer BS, Choudhary S, Vijayvergia R, In vitro anti-inflammatory, analgesic and acute toxicity studies of ethanol
extracts of Andrographis paniculata Nees and Spilanthus acemella Murr. Der Pharmacia Sinica 2012; 3 (5):590-593.
http://pelagiaresearchlibrary.com/der-pharmacia-sinica/vol3-iss5/DPS-2012-3-5-590-593.pdf |
| 10. |
Zhang XF, Tan BK, Antidiabetic
property of ethanolic extract of Andrographis paniculata in
streptozotocindiabetic
rats. Acta Pharmacol Sin. 2000;21(12):1157-64.
http://www.ncbi.nlm.nih.gov/pubmed/11603293 |
