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Andrographis paniculata

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GENERAL FEATURES

Name: Andrographis paniculata
Synonyms/Scientific names: Andrographis paniculata (Burm f.) Nees[1]
Synonyms/common names :
Andrographis, Green chirayta, creat, king of bitters,Kalmegh, Kalamegha[1]
English name:
Trade name:
Kan Jang®, a herbal preparation containg extract of A. panculata[2]
Description: Family : Acanthaceae[1]
Extract used:
Phyto-constituents
(active):
5,7,2',3'-tetramethoxyflavanone and 5-hydroxy-7,2',3'-trimethoxyflavone, andrographolide diterpenoids, and polyphenols[3]
7-O-methylwogonin ,
7-O-methyldihydrowogonin ,
5-hydroxy-7, 8, 2', 5'-tetramethoxy-flavone ,
skullcapflavone-2'-methoxylether ,
5-hydroxy-7, 8, 2', 3'-tetramethoxyflavone ,
5, 4'-dihydroxy-7, 8, 2', 3'-tetramethoxyflavone,
dihydroskullcapflavone ,
5, 7, 8-trimethoxydihydroflavone ,
5, 2'-dihydroxy-7, 8-dimethoxyflvone ,
andrographidine C ,
5, 7, 4'-trihydroxyflavone ,
5, 7, 3', 4'-tetrahydroxyflavone[4]
Aerial parts:
neoandrographolide,
3, 14-di-deoxyandrographolide ,
andrographolide,
14-deoxy-11, 12-didehydroandrographolide,
19-hydroxy-8 (17), 13-labdadien-15, 16-olide,
14-deoxy-andrographolide ,
3-oxo-14-deoxy-andrographolide ,
isoandrographolide ,
bisandrographolide ,
deoxyandrographiside ,
14-deoxy-11, 12-didehydroandrographiside,
andrographiside[5]
3-O-beta-D-glucosyl-14-deoxyandrographiside and 3-O-beta-D-glucosyl-14-deoxy-11,12-didehydroandrographiside[6]
Actions
& Indications:
Pharmcological Action-
hepatoprotective in mice[7]
antioxidant and anti-inflammatory in mice[8]
analgesic in rats[9]
antidiabetic in rats[10]
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Chapter 3 : Pharmacognostical Profile of Selected Medicinal Plants ; In :Handbook of African Medicinal Plants, Second Edition, by Iwu MM, CRC Press, 2014, Page no. 140.
https://books.google.com/books?id=GictAgAAQBAJ&pg=PA140
2. Spasov AA et al, Comparative controlled study of Andrographis fixed combination, Kan Jang® and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res. 2004;18(1):4753.
http://dx.doi.org/10.1002/ptr.1359
3. Koteswara Rao Y et al, Flavonoids and andrographolides from Andrographis paniculata. Phytochemistry. 2004;65(16):2317-21.
http://dx.doi.org/10.1016/j.phytochem.2004.05.008
4. Chen LX, Qu GX, Qiu F, Studies on flavonoids of Andrographis paniculata. Zhongguo Zhong Yao Za Zhi. 2006 ;31(5):391-5.
http://www.ncbi.nlm.nih.gov/pubmed/16711423
5. Chen LX, Qu GX, Qiu F, Studies on diterpenoids from Andrographis paniculata. Zhongguo Zhong Yao Za Zhi. 2006 ;31(19):1594-7.
http://www.ncbi.nlm.nih.gov/pubmed/17165582
6. Zhou KL et al, Two new entlabdane diterpenoid glycosides from the aerial parts of Andrographis paniculata. J Asian Nat Prod Res. 2008 ;10( 9-10):939-43.
http://dx.doi.org/10.1080/10286020802217432
7. Nagalekshmi R et al, Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food Chem Toxicol. 2011;49(12):3367-73.
http://dx.doi.org/10.1016/j.fct.2011.09.026
8. Sheeja K, Shihab PK, Kuttan G, Antioxidant and anti-inflammatory activities of the plant Andrographis Paniculata Nees. Immunopharmacology and Immunotoxicology 2006;28(1):129-140.
http://dx.doi.org/10.1080/08923970600626007
9. Tanweer BS, Choudhary S, Vijayvergia R, In vitro anti-inflammatory, analgesic and acute toxicity studies of ethanol extracts of Andrographis paniculata Nees and Spilanthus acemella Murr. Der Pharmacia Sinica 2012; 3 (5):590-593.
http://pelagiaresearchlibrary.com/der-pharmacia-sinica/vol3-iss5/DPS-2012-3-5-590-593.pdf
10. Zhang XF, Tan BK, Antidiabetic property of ethanolic extract of Andrographis paniculata in streptozotocindiabetic rats. Acta Pharmacol Sin. 2000;21(12):1157-64.
http://www.ncbi.nlm.nih.gov/pubmed/11603293