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AEOL-10150

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
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GENERAL FEATURES

Name: AEOL-10150
Synonyms: Mn(III) tetrakis(N,N'- diethylimidazolium-2-yl) porphyrin[1]
MnTDE-2-ImP5+[1]
Trade name: Molecule is developed by Aeolus Pharmaceuticals, Inc., CA, USA[2]
Chemical name:
Molecular Weight:
Source:
Structure: [3],[4]
Chemical Nature: AEOL-10150 is a small-molecule antioxidant analogous to the catalytic site of superoxide dismutase.[2]
AEOL 10150 is positively charged, and the positive charges are present on the four pyridyl or imidizol groups in the compound.[5]
Actions
& Indications:
Pharmcological Action-
Therapeutic indications:
Preclinical study-
Notes:
REFERENCES
1. Chapter 27: Superoxide dismutase mimics and other redox-active therapeutics by Haberle IB, Tovmasyan A; In :Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease, edited by Armstrong D, Stratton RD, John Wiley and Sons, 2016, page no. 416.
https://books.google.co.in/books?id=mAT9CgAAQBAJ&pg=PA416
2. Orrell RW, AEOL-10150 (Aeolus). Curr Opin Investig Drugs. 2006;7(1):70-80.
https://www.ncbi.nlm.nih.gov/pubmed/16425674
3. Day BJ, Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov Today. 2004;9(13):557-66.
http://dx.doi.org/10.1016/S1359-6446(04)03139-3
4. Garofalo MC et al, A Pilot study in Rhesus Macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage. Health Phys. 2014; 106 (1): 73-83.
http://dx.doi.org/10.1097/HP.0b013e3182a4d967
5. Crapo JD, Oxidative stress as an initiator of cytokine release and cell damage. Eur Respir J 2003; 22: Suppl. 44, 4s–6s.
http://dx.doi.org/10.1183/09031936.03.00000203a