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"Radiosensitisers and Radioprotectors"

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Nelumbo nucifera

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Action of Extract: acetone–water extract of Nelumbo nucifera Gaertn. can protect and/or stimulate the proliferation of hematopoietic stem cells[1]
Action on cell cycle:
NN-B-4 identified from N. nucifera ethanolic extracts significantly arrested the cell cycle progression of activated human peripheral blood mononuclear cells from the G1 transition to the S phase.[2]
Target: Nucleic Acid
acetone–water extract of Nelumbo nucifera Gaertn. pre-treatment protected against radiation-induced DNA single strandbreaks and chromosomal aberrations in mice[1]
acetone–water extract of Nelumbo nucifera Gaertn. pre-treatment reversed radiation-induced alteration in the levels of superoxide dismutase, catalase, glutathione peroxidase in mice liver[1]
acetone–water extract of Nelumbo nucifera Gaertn. pre-treatment reduced radiation-induced lipid peroxidation in mice liver[1]
Mechanism: ethanolic seed extract showed DPPH radical scavenging activity[3]
hydro alcoholic extract of Nelumbo nucifera seeds scavenged DPPH radical in vitro[4]
Nelumbo nucifera extract is suffested to protect mice against radiation by elevating endogenous antioxidant enzymes levels and reducing lipid peroxidation formation.[1]
1. Duan Y et al, Whole body radioprotective activity of an acetone–water extract from the seedpod of Nelumbo nucifera Gaertn. seedpod. Food and Chemical Toxicology 2010;48: 3374–3384.
2. Liu CP et al, The extracts from Nelumbo nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci. 2004 ;75(6):699-716.
3. Sohn DH et al, Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine. 2003;10(23): 165-9.
4. Rai S et al, Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethnopharmacol. 2006 ;104(3):322-7.