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Tinospora cordifolia

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


CHEMICAL INTERVENTION

Effective dose
(experimental):
Mode and form of
administration:
commercially available extract in form of capsules with brand name “guduchi” from the Himalaya Drug Co., Bangalore, India[1]
orally and Intraperitoneal in mice[2],[3],[4],[5],[6]
orally in humans[7]
Time of
administration:
Usually administered before radiation exposure as observed in animal experiments[2], [8],[3],[9]
Side Effects:
Combined action
with other drugs
/therapies:
methanolic leaf extract exhibited metal(ferrous ions) chelating activity in vitro[10],[11]
Precautions &
Contraindications:
REFERENCES
1. Goel B et al, Clinical evaluation of analgesic activity of Guduchi (Tinospora cordifolia) using animal model. Journal of Clinical and Diagnostic Research. 2014 ;8(8): HC01-HC04.
http://dx.doi.org/10.7860/JCDR/2014/9207.4671
2. Goel HC et al, Radioprotective poential of an herbal extract of Tinospora cordifolia. J. Radiat. Res. 2004;45(1):61-68.
http://dx.doi.org/10.1269/jrr.45.61
3. Singh L et al, Effect of Tinospora cordifolia on Gamma ray-induced perturbations in macrophages and splenocytes. J. Radiat. Res.2007; 48(4): 305–315.
http://dx.doi.org/10.1269/jrr.07001
4. Sharma R, In vivo delivery of Tinospora cordifolia root extract preventing radiation-induced dystrophies in mice ovaries. Evidence-Based Complementary and Alternative Medicine Volume 2015, Article ID 346427, 7 pages.
http://dx.doi.org/10.1155/2015/346427
5. Sharma P, Goyal PK, Modulation of biochemical and antioxidant enzymes in blood by Tinospora cordifolia against gamma radiation mediated damage in mice. Asian J Pharm Clin Res. 2015;8(3):106-112.
http://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/4662/2434
6. Pahadiya S, Sharma J, Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytother. Res. 2003; 17:552–554.
http://dx.doi.org/10.1002/ptr.1156
7. Amruthesh S et al, Evaluation of radioprotective effects of Tinospora cordifolia in patients on radiotherapy for squamous cell carcinoma of the Head & neck- A pilot study. International Journal of Contemporary Dentistry. 2010;1(1):24-30.
http://edentj.com/index.php/ijcd/article/view/14/4
8. Rao SK, Rao PS, Alteration in the radiosensitivity of HeLa cells by Dichloromethane extract of Guduchi (Tinospora cordifolia). Integrative Cancer Therapies 2010; 9(4): 378–384.
http://dx.doi.org/10.1177/1534735410387598
9. Jagetia GC, Nayak V, Vidhyasagar MS, Enhancement of radiation effect by Guduchi (Tinospora cordifolia) in HeLa cells. Pharmaceutical Biology. 2002;40(3):179-188.
http://cat.inist.fr/?aModele=afficheN&cpsidt=13754577
10. Praveen N et al, Antioxidant activity of Tinospora cordifolia leaf extracts through non-enzymatic method. Journal of Medicinal Plants Research 2012;6(33):4790-4795.
http://dx.doi.org/10.5897/JMPR12.200
11. Goel HC, Kumar IP, Rana SVS, Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection. Indian J. Exp. Biol. 2002;40:727-734.
http://www.ncbi.nlm.nih.gov/pubmed/12587720