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Syzygium cumini

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


CHEMICAL INTERVENTION

Effective dose
(experimental):
In cases of radioprotective studues, exceding a particular concentration, leaf extract is reported to start manifesting its toxic effects and resulted in decline of radioprotective effect.[1],[2]
Mode and form of
administration:
orally[3],[4],[5], and Intraperitoneal [6],[2]
Required amount of extract is dissolved in 1% carboxymethyl cellulose (CMC) in sterile normal physiological saline to be given orally in mice in vivo radioprotection studies[3],[4]
The extract was more effective in radioprotection when administered through the intraperitoneal route at equimolar doses than the oral route in an in vivo study with mice[6]
Time of
administration:
Side Effects:
Combined action
with other drugs
/therapies:
Aqueous alcoholic seed extract, stem bark extract and ellagitannin from fruit extract scavenged Ferric ion reducing antioxidant activity in vitro[7],[8], [9],[10]
Precautions &
Contraindications:
REFERENCES
1. Jagetia GC, Baliga MS, Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicology Letters. 2002; 132(1) : 19–25.
http://dx.doi.org/10.1016/S0378-4274(02)00032-2
2. Jagetia GC, Baliga MS, Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation. Nahrung/Food. 2003;47(3):181 – 185.
http://dx.doi.org/10.1002/food.200390042
3. Jagetia GC, Shetty PC, Vidyasagar MS, Inhibition of radiation-induced DNA damage by Jamun, Syzygium cumini, in the cultured splenocytes of mice exposed to different doses of γ-radiation. Integrative Cancer Therapies. 2012; 11(2): 141– 153.
http://dx.doi.org/10.1177/1534735411413261
4. Jagetia GC, Shetty PC, Vidyasagar MS, Treatment of mice with leaf extract of jamun(Syzygium cumini Linn. Skeels)protects against the radiation-induced damage in the intestinal mucosa of mice exposed to different doses of γ-radiation. Pharmacologyonline. 2008; 1: 169-195.
http://pharmacologyonline.silae.it/files/archives/2008/vol1/18_Ganesh.pdf
5. Sharma A, Soyal D, Goyal PK, Radioprotection by seed extract of Syzygium cumini in normal tissues of fibrosarcoma bearing mice. Indian Society for Radiation Biology, Delhi (India); K.S. Hegde Medical Academy, Mangalore (India); 90 p; Oct 2013; p. 61; ICRB-2013: international conference on radiation biology and clinical applications; Mangalore (India); 25-27 Oct 2013.
https://inis.iaea.org/search/search.aspx?orig_q=RN:45108336
6. Jagetia GC, Baliga MS, Venkatesh P, Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of γ -radiation. J. Radiat. Res. 2005; 46(1): 59–65.
http://dx.doi.org/10.1269/jrr.46.59
7. Vasi S, Austin A, Antioxidant potential ofEugenia jambolana Lam. seeds. J. Biol. Sci. 2009;9(8):894-898.
http://dx.doi.org/10.3923/jbs.2009.894.898
8. Ruan ZP, Zhang LL, Lin YM, Evaluation of the antioxidant activity of Syzygium cumini leaves. Molecules. 2008; 13: 2545-2556.
http://dx.doi.org/10.3390/molecules13102545
9. Zhang LL, Lin YM, Antioxidant tannins from Syzygium cumini fruit. Afr. J. Biotechnol. 2009;8 (10):2301-2309.
http://www.ajol.info/index.php/ajb/article/view/60578
10. Sudeep HV, Ramachandra YL, Rai SP, Investigation of in vitro, in vivo antioxidant and hepatoprotective activities of Eugenia jambolana Lam. stem bark. Journal of Pharmacy Research. 2011;4(11):4167-4171.
http://eprints.manipal.edu/139858/