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Nigella sativa

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General Features                  Clinical Study                  Chemical Intervention                 Pharmacological Aspects                 
Radiobiological Aspects                  Biological Models                  Biological Target                  Toxicity                 


CHEMICAL INTERVENTION

Effective dose
(experimental):
Mode and form of
administration:
Intraperitoneal[1],[2] and oral[3],[4]
Time of
administration:
before irradiation[3],[1],[4]
Side Effects:
Combined action
with other drugs
/therapies:
N. sativa essential oil exhibited ferrous ion chelating activity[5]
Precautions &
Contraindications:
REFERENCES
1. Cemek M et al, In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats. Photochemistry and Photobiology 2006; 82: 1691-1696.
http://dx.doi.org/10.156212006-06-15-RA-924
2. Demir E et al, The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract
http://dx.doi.org/10.1007/s00508-015-0736-4
3. Jagetia GC, Ravikiran PB, Radioprotective potential of Nigella Sativa extract in Swiss Albino Mice exposed to whole Body γ-radiation. Altern Integr Med 2014; 3(4):1-9.
http://dx.doi.org/10.4172/2327-5162.1000168
4. Rastogi L et l, Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L. Int. J. Radiat. Biol. 2010;86(9):719–731.
http://dx.doi.org/10.3109/09553002.2010.484480
5. Singh S et al, Composition, in vitro antioxidant and antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (Nigella sativa L.). BioMed Research International Volume 2014, Article ID 918209, 10 pages
http://dx.doi.org/10.1155/2014/918209